Prostaglandin EP4 receptor

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PTGER4
Identifiers
Aliases PTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4
External IDs MGI: 104311 HomoloGene: 20261 GeneCards: PTGER4
Targeted by Drug
treprostinil, prostaglandin D2, alprostadil, dinoprostone, dinoprost, [[d:Q9254396|]], U46619[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000958

NM_001136079
NM_008965

RefSeq (protein)

NP_000949.1

NP_032991.1

Location (UCSC) Chr 5: 40.68 – 40.69 Mb Chr 15: 5.21 – 5.24 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Prostaglandin E2 receptor 4 (EP4) is a prostaglandin receptor encoded by the PTGER4 gene in humans.

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.[4]

See also[edit]

References[edit]

External links[edit]

  • "Prostanoid Receptors: EP4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.