EPH receptor A1

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EPHA1
Protein EPHA1 PDB 1x5a.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEPHA1, Epha1, 5730453L17Rik, AL033318, Eph, Esk, EPHT, EPHT1, EPH receptor A1, EPH
External IDsMGI: 107381 HomoloGene: 3835 GeneCards: EPHA1
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for EPHA1
Genomic location for EPHA1
Band7q34-q35Start143,390,289 bp[1]
End143,408,892 bp[1]
RNA expression pattern
PBB GE EPHA1 205977 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005232

NM_023580

RefSeq (protein)

NP_005223

NP_076069

Location (UCSC)Chr 7: 143.39 – 143.41 MbChr 6: 42.36 – 42.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.[5][6]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.[6]

References[edit]

  1. ^ a b c ENSG00000284816 GRCh38: Ensembl release 89: ENSG00000146904, ENSG00000284816 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029859 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
  6. ^ a b "Entrez Gene: EPHA1 EPH receptor A1".

Further reading[edit]