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Available structures
PDB Ortholog search: PDBe RCSB
Aliases EPHB3, ETK2, HEK2, TYRO6, EPH receptor B3
External IDs MGI: 104770 HomoloGene: 20938 GeneCards: EPHB3
RNA expression pattern
PBB GE EPHB3 1438 at fs.png

PBB GE EPHB3 204600 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 184.56 – 184.58 Mb Chr 16: 21.2 – 21.22 Mb
PubMed search [1] [2]
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Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.[3][4]


Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[4]


EPHB3 has been shown to interact with MLLT4[5] and RAS p21 protein activator 1.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Böhme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rübsamen-Waigmann H (Oct 1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2". Oncogene. 8 (10): 2857–62. PMID 8397371. 
  4. ^ a b "Entrez Gene: EPHB3 EPH receptor B3". 
  5. ^ Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rübsamen-Waigmann H, Strebhardt K (Aug 1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. doi:10.1073/pnas.95.17.9779. PMC 21413Freely accessible. PMID 9707552. 
  6. ^ Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K (Jul 1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions". Oncogene. 17 (2): 255–60. doi:10.1038/sj.onc.1201907. PMID 9674711. 

Further reading[edit]