EPH receptor B4

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Protein EPHB4 PDB 2bba.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases EPHB4, Ephb4, AI042935, Htk, MDK2, Myk1, Tyro11, EPH receptor B4, HTK, MYK1, TYRO11
External IDs MGI: 104757 HomoloGene: 20939 GeneCards: 2050
RNA expression pattern
PBB GE EPHB4 202894 at tn.png

PBB GE EPHB4 216680 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 100.8 – 100.83 Mb Chr 5: 137.35 – 137.38 Mb
PubMed search [1] [2]
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Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.[1][2]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.[2][3]


  1. ^ Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT (Jun 1994). "Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily". J Biol Chem 269 (19): 14211–8. PMID 8188704. 
  2. ^ a b "Entrez Gene: EPHB4 EPH receptor B4". 
  3. ^ Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). "Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.". Mol. Cell 4 (3): 403–14. doi:10.1016/S1097-2765(00)80342-1. PMID 10518221. 

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