EPH receptor B4

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Protein EPHB4 PDB 2bba.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases EPHB4, Ephb4, AI042935, Htk, MDK2, Myk1, Tyro11, EPH receptor B4, HTK, MYK1, TYRO11, HFASD
External IDs MGI: 104757 HomoloGene: 20939 GeneCards: EPHB4
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for EPHB4
Genomic location for EPHB4
Band 7q22.1 Start 100,802,565 bp[1]
End 100,827,521 bp[1]
RNA expression pattern
PBB GE EPHB4 216680 s at fs.png

PBB GE EPHB4 202894 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 100.8 – 100.83 Mb Chr 7: 137.35 – 137.38 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.[5][6]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.[6][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196411 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029710 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT (Jun 1994). "Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily". J Biol Chem. 269 (19): 14211–8. PMID 8188704. 
  6. ^ a b "Entrez Gene: EPHB4 EPH receptor B4". 
  7. ^ Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). "Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development". Mol. Cell. 4 (3): 403–14. doi:10.1016/S1097-2765(00)80342-1. PMID 10518221. 

Further reading[edit]