EPH receptor A1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
EPHA1
Protein EPHA1 PDB 1x5a.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EPHA1, Epha1, 5730453L17Rik, AL033318, Eph, Esk, EPHT, EPHT1, EPH receptor A1, EPH
External IDs MGI: 107381 HomoloGene: 3835 GeneCards: EPHA1
RNA expression pattern
PBB GE EPHA1 205977 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005232

NM_023580

RefSeq (protein)

NP_005223

NP_076069.2
NP_076069

Location (UCSC) Chr 7: 143.39 – 143.41 Mb Chr 6: 42.36 – 42.37 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.[3][4]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
  4. ^ a b "Entrez Gene: EPHA1 EPH receptor A1". 

Further reading[edit]