EPH receptor B1

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EPH receptor B1
Protein EPHB1 PDB 2djs.png
PDB rendering based on 2djs.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EPHB1 ; ELK; EPHT2; Hek6; NET
External IDs OMIM600600 MGI1096337 HomoloGene20936 ChEMBL: 5072 GeneCards: EPHB1 Gene
EC number 2.7.10.1
Orthologs
Species Human Mouse
Entrez 2047 270190
Ensembl ENSG00000154928 ENSMUSG00000032537
UniProt P54762 Q8CBF3
RefSeq (mRNA) NM_004441 NM_001168296
RefSeq (protein) NP_004432 NP_001161768
Location (UCSC) Chr 3:
134.6 – 135.26 Mb
Chr 9:
101.92 – 102.35 Mb
PubMed search [1] [2]

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.[1][2]

Function[edit]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[2]

Interactions[edit]

EPH receptor B1 has been shown to interact with:

References[edit]

  1. ^ Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE et al. (Aug 1996). "cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain". Genomics 29 (2): 426–37. doi:10.1006/geno.1995.9985. PMID 8666391.  Check date values in: |year= / |date= mismatch (help)
  2. ^ a b "Entrez Gene: EPHB1 EPH receptor B1". 
  3. ^ Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL et al. (Mar 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes Dev. 12 (5): 667–78. doi:10.1101/gad.12.5.667. PMC 316584. PMID 9499402. 
  4. ^ Han DC, Shen TL, Miao H, Wang B, Guan JL (Nov 2002). "EphB1 associates with Grb7 and regulates cell migration". J. Biol. Chem. 277 (47): 45655–61. doi:10.1074/jbc.M203165200. PMID 12223469. 
  5. ^ Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO (Jan 1998). "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase". J. Biol. Chem. 273 (3): 1303–8. doi:10.1074/jbc.273.3.1303. PMID 9430661. 

Further reading[edit]