ERAP2

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ERAP2
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases ERAP2, L-RAP, LRAP, endoplasmic reticulum aminopeptidase 2
External IDs HomoloGene: 75183 GeneCards: ERAP2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130140
NM_022350
NM_001329229
NM_001329233

n/a

RefSeq (protein)

NP_001123612
NP_001316158
NP_001316162
NP_071745

n/a

Location (UCSC) Chr 5: 96.88 – 96.92 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Endoplasmic reticulum aminopeptidase 2 is a protein that in humans is encoded by the ERAP2 gene.[2]

Function[edit]

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2).[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Entrez Gene: Endoplasmic reticulum amino peptidase 2". 
  3. ^ Tanioka T, Hattori A, Masuda S, Nomura Y, Nakayama H, Mizutani S, Tsujimoto M (Aug 2003). "Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases". The Journal of Biological Chemistry. 278 (34): 32275–83. PMID 12799365. doi:10.1074/jbc.M305076200. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.