ERC2 (gene)

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AliasesERC2, CAST, CAST1, ELKSL, SPBC110, Spc110, ELKS/RAB6-interacting/CAST family member 2
External IDsOMIM: 617250 MGI: 1098749 HomoloGene: 69188 GeneCards: ERC2
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ERC2
Genomic location for ERC2
Band3p14.3Start55,508,311 bp[1]
End56,468,467 bp[1]
RNA expression pattern
PBB GE ERC2 213938 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 55.51 – 56.47 MbChr 14: 27.62 – 28.48 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

ERC protein 2 is a protein that in humans is encoded by the ERC2 gene.[5]


ERC2 (gene) has been shown to interact with PPFIA4,[6] RIMS1,[7][8] UNC13A,[9] and liprin-alpha-1.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187672 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040640 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ERC2 ELKS/RAB6-interacting/CAST family member 2".
  6. ^ a b Ko J, Na M, Kim S, Lee JR, Kim E (October 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". The Journal of Biological Chemistry. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
  7. ^ Takao-Rikitsu E, Mochida S, Inoue E, Deguchi-Tawarada M, Inoue M, Ohtsuka T, Takai Y (January 2004). "Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release". The Journal of Cell Biology. 164 (2): 301–11. doi:10.1083/jcb.200307101. PMC 2172332. PMID 14734538.
  8. ^ Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". The Journal of Cell Biology. 158 (3): 577–90. doi:10.1083/jcb.200202083. PMC 2173811. PMID 12163476.
  9. ^ "Protein unc-13 homolog A". UniProt.

Further reading[edit]