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ER lipid raft associated 2
Symbols ERLIN2 ; C8orf2; Erlin-2; NET32; SPFH2; SPG18
External IDs OMIM611605 MGI2387215 HomoloGene5193 GeneCards: ERLIN2 Gene
RNA expression pattern
PBB GE ERLIN2 221543 s at tn.png
PBB GE ERLIN2 221542 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11160 244373
Ensembl ENSG00000147475 ENSMUSG00000031483
UniProt O94905 Q8BFZ9
RefSeq (mRNA) NM_001003790 NM_153592
RefSeq (protein) NP_001003790 NP_705820
Location (UCSC) Chr 8:
37.74 – 37.76 Mb
Chr 8:
27.02 – 27.04 Mb
PubMed search [1] [2]

Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene.[1][2][3][4]

Model organisms[edit]

Model organisms have been used in the study of ERLIN2 function. A conditional knockout mouse line called Erlin2tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]


  1. ^ Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (Oct 1999). "Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9". Cytogenet Cell Genet 85 (3–4): 227–31. doi:10.1159/000015298. PMID 10449903. 
  2. ^ Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C (Aug 2005). "A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes". Oncogene 24 (33): 5235–45. doi:10.1038/sj.onc.1208741. PMID 15897872. 
  3. ^ Browman DT, Resek ME, Zajchowski LD, Robbins SM (Jul 2006). "Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER". J Cell Sci 119 (Pt 15): 3149–60. doi:10.1242/jcs.03060. PMID 16835267. 
  4. ^ "Entrez Gene: ERLIN2 ER lipid raft associated 2". 
  5. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  6. ^ a b "International Mouse Phenotyping Consortium". 
  7. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  8. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  9. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  10. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  11. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]