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For the video game commonly abbreviated as ETS2, see Euro Truck Simulator 2.
Protein ETS2 PDB 1k78.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases ETS2, ETS2IT1, ETS proto-oncogene 2, transcription factor
External IDs MGI: 95456 HomoloGene: 3838 GeneCards: 2114
RNA expression pattern
PBB GE ETS2 201328 at tn.png

PBB GE ETS2 201329 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 21: 38.81 – 38.82 Mb Chr 16: 95.7 – 95.72 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Protein C-ets-2 is a protein that in humans is encoded by the ETS2 gene.[3][4] The protein encoded by this gene belongs to the ETS family of transcription factors.[3]


ETS2 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Dwyer J, Li H, Xu D, Liu JP (Oct 2007). "Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family". Annals of the New York Academy of Sciences. 1114 (1): 36–47. doi:10.1196/annals.1396.022. PMID 17986575. 
  4. ^ "Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)". 
  5. ^ a b Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (Oct 1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner". The Journal of Biological Chemistry. 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. PMID 9334186. 
  6. ^ Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931. 
  7. ^ Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP (Feb 1992). "Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1291–5. doi:10.1073/pnas.89.4.1291. PMC 48435free to read. PMID 1741383. 
  8. ^ Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC. "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID 12894593. 

Further reading[edit]

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