ETV4

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ETV4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesETV4, E1A-F, E1AF, PEA3, PEAS3, ETS variant 4, ETS variant transcription factor 4
External IDsOMIM: 600711 MGI: 99423 HomoloGene: 1504 GeneCards: ETV4
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ETV4
Genomic location for ETV4
Band17q21.31Start43,527,844 bp[1]
End43,579,620 bp[1]
RNA expression pattern
PBB GE ETV4 211603 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008815
NM_001316365
NM_001316366

RefSeq (protein)

NP_001303294
NP_001303295
NP_032841

Location (UCSC)Chr 17: 43.53 – 43.58 MbChr 11: 101.77 – 101.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors.[5][6][7]

Disease marker[edit]

Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing's Sarcoma. While both are cancerous tumors, the former grows in the bones most commonly affecting the arms, legs, hips, and spine, while the later affects the soft tissue in the chest, foot, pelvis and spine.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175832 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017724 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K (Jul 1995). "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21". Genomics. 28 (2): 357–9. doi:10.1006/geno.1995.1158. PMID 8530053.
  6. ^ "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)".
  7. ^ "ETV4 Gene - GeneCards | ETV4 Protein | ETV4 Antibody". www.genecards.org. Retrieved 2019-10-20.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.