EZH1

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EZH1
Identifiers
Aliases EZH1, KMT6B, enhancer of zeste 1 polycomb repressive complex 2 subunit
External IDs MGI: 1097695 HomoloGene: 20458 GeneCards: EZH1
RNA expression pattern
PBB GE EZH1 203249 at fs.png

PBB GE EZH1 32259 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001991
NM_001321079
NM_001321081
NM_001321082

NM_007970

RefSeq (protein)

NP_001308008
NP_001308010
NP_001308011
NP_001982

NP_031996.1
NP_031996

Location (UCSC) Chr 17: 42.7 – 42.75 Mb Chr 11: 101.19 – 101.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene.[3][4]

Function[edit]

In mice, EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.[5] EZH1 also complements EZH2 in maintaining stem cell identity and executing pluripotency.[6]


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Abel KJ, Brody LC, Valdes JM, Erdos MR, McKinley DR, Castilla LH, Merajver SD, Couch FJ, Friedman LS, Ostermeyer EA, Lynch ED, King MC, Welcsh PL, Osborne-Lawrence S, Spillman M, Bowcock AM, Collins FS, Weber BL (Feb 1997). "Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1". Genomics. 37 (2): 161–71. doi:10.1006/geno.1996.0537. PMID 8921387. 
  4. ^ "Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)". 
  5. ^ Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E (Mar 2011). "EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.". Genes Dev. 25 (5): 485–98. doi:10.1101/gad.2019811. PMC 3049289Freely accessible. PMID 21317239. 
  6. ^ Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH (Nov 2008). "EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.". Mol Cell. 32 (4): 491–502. doi:10.1016/j.molcel.2008.10.016. PMC 2630502Freely accessible. PMID 19026780. 

Further reading[edit]