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Skeletal formula of ebselen
Ball-and-stick model of the ebselen molecule
IUPAC name
60940-34-3 YesY
ChemSpider 3082 YesY
Jmol interactive 3D Image
PubChem 3194
Molar mass 274.17666
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Ebselen (also called PZ 51, DR3305, and SPI-1005), is a synthetic organoselenium drug molecule with anti-inflammatory, anti-oxidant and cytoprotective activity. It acts as a mimic of glutathione peroxidase and can also react with peroxynitrite.[1] It is being investigated as a possible treatment for reperfusion injury and stroke,[2][3] hearing loss and tinnitus,[4] and bipolar disorder.[5][6]

Additionally, ebselen may be effective against Clostridium difficile infections.[7]

Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides. Several ebselen analogues have been shown to scavenge hydrogen peroxide in the presence of thiols.[8]


  1. ^ Schewe T (1995). "Molecular actions of ebselen--an antiinflammatory antioxidant". Gen Pharmacol 26 (6): 1153–69. doi:10.1016/0306-3623(95)00003-J. PMID 7590103. 
  2. ^ Parnham M, Sies H (2000). "Ebselen: prospective therapy for cerebral ischaemia". Expert Opin Investig Drugs 9 (3): 607–19. doi:10.1517/13543784.9.3.607. PMID 11060699. 
  3. ^ Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, Yasuhara H (1 January 1998). "Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group". Stroke 29 (1): 12–7. doi:10.1161/01.STR.29.1.12. PMID 9445321. 
  4. ^ Kil, Jonathan; Pierce, Carol; Tran, Huy; Gu, Rende; Lynch, Eric D (2007). "Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase". Hearing Research 226 (1–2): 44–51. doi:10.1016/j.heares.2006.08.006. PMID 17030476. 
  5. ^ Singh, N.; Halliday, A. C.; Thomas, J. M.; Kuznetsova, O. V.; Baldwin, R.; Woon, E. C. Y.; Aley, P. K.; Antoniadou, I.; Sharp, T.; Vasudevan, S. R.; Churchill, G. C. (2013). "A safe lithium mimetic for bipolar disorder". Nature Communications 4: 1332. doi:10.1038/ncomms2320. PMC 3605789. PMID 23299882. 
  6. ^ "New drug for bipolar disorder may offer fewer side effects". University of Oxford Latest News. 2013-01-08. Retrieved 12 January 2013. 
  7. ^ http://medicalxpress.com/news/2015-09-drug-deadly-difficile-bacteria-healthy.html
  8. ^ Satheeshkumar K, Mugesh G (2011). "Synthesis and Antioxidant Activity of Peptide-Based Ebselen Analogues.". Chem. Eur. J. 17 (17): 4849–57. doi:10.1002/chem.201003417.