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Description comprehensive database of Escherichia coli biology.
Organisms Escherichia coli
Research center SRI International
Laboratory SRI International
Primary citation Keseler & al. (2011)[1]

EcoCyc is a bioinformatics database for the bacterium Escherichia coli K-12. The EcoCyc project performs literature-based curation of the E. coli genome, and of E. coli transcriptional regulation, transporters, and metabolic pathways.

EcoCyc is a regularly updated electronic encyclopedia that contains written summaries of E. coli genes, distilled from more than 16,000 scientific articles.

EcoCyc is also a computable description of the genome and cellular networks of E. coli that supports data mining and computational analyses.

Objects in the EcoCyc database describe each E. coli gene and gene product. Database objects also describe molecular interactions, including metabolic pathways, transport events, and the regulation of gene expression.

EcoCyc provides several genome-scale visualization tools to aid in the analysis of omics data, such as by painting gene expression or metabolomics data onto the full regulatory network of E. coli.

EcoCyc can be accessed through the EcoCyc web site, as a set of downloadable files, and in conjunction with the Pathway Tools software that can be installed locally on Macintosh, PC/Windows, and PC/Linux computers. The downloadable software provides capabilities that go well beyond the web version of EcoCyc.


  1. ^ Keseler, Ingrid M; Collado-Vides Julio, Santos-Zavaleta Alberto, Peralta-Gil Martin, Gama-Castro Socorro, Muñiz-Rascado Luis, Bonavides-Martinez César, Paley Suzanne, Krummenacker Markus, Altman Tomer, Kaipa Pallavi, Spaulding Aaron, Pacheco John, Latendresse Mario, Fulcher Carol, Sarker Malabika, Shearer Alexander G, Mackie Amanda, Paulsen Ian, Gunsalus Robert P, Karp Peter D (Jan 2011). "EcoCyc: a comprehensive database of Escherichia coli biology". Nucleic Acids Res. (England) 39 (Database issue): D583–90. doi:10.1093/nar/gkq1143. PMC 3013716. PMID 21097882. 

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