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Clinical data
Trade namesSavaysa, Lixiana, others
AHFS/Drugs.comConsumer Drug Information
License data
  • US: C (Risk not ruled out)
Routes of
By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability62%; Tmax 1–2 hours
Protein binding55%
MetabolismMinimal liver
Elimination half-life10–14 hours
Excretion50% kidney; <50% bile
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass548.056 g/mol g·mol−1
3D model (JSmol)
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Edoxaban (trade names Savaysa, Lixiana) is an oral anticoagulant drug which acts as a direct factor Xa inhibitor. Compared to warfarin it has fewer interactions with other medications.[1]

It was developed by Daiichi Sankyo and approved in July 2011 in Japan for prevention of venous thromboembolisms (VTE) following lower-limb orthopedic surgery.[2] It was also approved by the FDA in January 2015 for the prevention of stroke and non–central-nervous-system systemic embolism.[3]

Medical uses[edit]

US FDA-labeled indications:

Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5 to 10 days of initial therapy with a parenteral anticoagulant.
To reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF)


It is also contraindicated in people with active pathological bleeding.[4]

Edoxaban works less well than warfarin in nonvalvular atrial fibrillation (NVAF) with a creatinine clearance (CrCl) greater than 95 mL/minute.[5]

Adverse effects[edit]

More common

  • bloody nose
  • heavy non-menstrual vaginal bleeding
  • pale skin
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • bloody or black, tarry stools
  • vomiting of blood or material that looks like coffee grounds
  • rash


  • confusion
  • cough
  • difficulty with speaking
  • double vision
  • fever
  • headache, sudden, severe
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • nausea and vomiting
  • slow speech[6]

Spinal or epidural hematomas resulting in long-term or permanent paralysis may occur with neuraxial anesthesia (epidural or spinal anesthesia) or spinal/epidural puncture; the risk is increased by the use of indwelling epidural catheters, concomitant administration of other drugs that affect hemostasis (e.g., NSAIDs, platelet inhibitors, other anticoagulants), in patients with a history of traumatic or repeated epidural or spinal punctures, a history of spinal deformity or surgery, or if optimal timing between the administration of edoxaban and neuraxial procedures is not known.[7]

Mechanism of action[edit]

Edoxaban inhibits free factor Xa and prothrombinase activity and inhibits thrombin-induced platelet aggregation. Inhibition of factor Xa in the coagulation cascade reduces thrombin generation and thrombus formation.[4][7]

Factor Xa[edit]

Factor Xa (FXa) is an essential blood coagulation factor[8] that is responsible for the initiation of the coagulation cascade. FXa cleaves prothrombin to its active form thrombin, which then acts to convert soluble fibrinogen to insoluble fibrin and to activate platelets. Stabilization of the platelet aggregation by fibrin mesh ultimately leads to clot formation.[9]

Related medications[edit]

A number of anticoagulants inhibit the activity of Factor Xa. Unfractionated heparin (UFH), low molecular weight heparin (LMWH), and fondaparinux inhibit the activity of factor Xa indirectly by binding to circulating antithrombin (AT III). These agents must be injected. Warfarin, phenprocoumon, and acenocoumarol are orally active vitamin K antagonists (VKA) which decrease hepatic synthesis of a number of coagulation factors, including Factor X. In recent years, a new series of oral, direct acting inhibitors of Factor Xa have entered clinical development. These include rivaroxaban, apixaban, betrixaban, LY517717, darexaban (YM150), and edoxaban (DU-176b).[10] Andexxa has been studied as a reversal agent for edoxaban, but has not received FDA approval so far.


  1. ^ Kiser, Kathryn (2017). Oral Anticoagulation Therapy: Cases and Clinical Correlation. Springer. p. 11. ISBN 9783319546438.
  2. ^ "First market approval in Japan for LIXIANA (Edoxaban)". Press Release. Daiichi Sankyo Europe GmbH. 2011-04-22. Archived from the original on 2013-11-06.
  3. ^ O'Riordan, Michael (9 January 2015). "FDA Approves Edoxaban for Stroke Prevention in AF and DVT/PE Prevention". Medscape. Retrieved 10 January 2015.
  4. ^ a b Savaysa (edoxaban) [prescribing information]. Parsippany, NJ: Daiichi Sankyo; January 2015.
  5. ^ "Highlights of prescribing information edoxaban" (PDF). Retrieved 8 May 2019.
  6. ^ https://www.drugs.com/cons/edoxaban.html
  7. ^ a b lexicomp.com
  8. ^ Yoshiyuki, I., et al. "Biochemical and pharmalogical profile of darexaban, an oral direct Xa inhibitor." European Journal of Pharmacology (2011): 49–55
  9. ^ Katsung, B., S. Masters and A. Trevor. Basic and Clinical Pharmacology 11th Edition. United States: McGraw-Hill, 2009
  10. ^ Turpie AG (January 2008). "New oral anticoagulants in atrial fibrillation". European Heart Journal. 29 (2): 155–65. doi:10.1093/eurheartj/ehm575. PMID 18096568.