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Clinical data
ATC code
CAS Number
PubChem CID
ECHA InfoCard 100.035.645
Chemical and physical data
Formula C11H16N2O5
Molar mass 256.25514
3D model (JSmol)
 NYesY (what is this?)  (verify)

Edoxudine (or edoxudin) is an antiviral drug. It is an analog of thymidine, a nucleoside.

It has shown effectiveness against herpes simplex virus.[1]


Edoxudine synthesis:[2] Synthesis via organopalladium intermediates:[3][4]

Mercuration of the 2'-deoxyuridine 1 leads to the organometallic derivative 2; reaction of that with ethylene in the presence dilithiopalladium tetrachloride gives the alkylation product 3; this is reduced catalytically in situ. There is thus obtained the antiviral agent edoxudine 4.


  1. ^ "Topical antiviral agents for herpes simplex virus infections". Drugs Today. 34 (12): 1013–25. December 1998. PMID 14743269. doi:10.1358/dot.1998.34.12.487486. 
  2. ^ K. K. Gauri, GB 1170565; eidem, U.S. Patent 3,553,192 (1968, 1971 both to Robugen).
  3. ^ Bergstrom, Donald E.; Ruth, Jerry L. (1976). "Synthesis of C-5 substituted pyrimidine nucleosides via organopalladium intermediates". Journal of the American Chemical Society. 98 (6): 1587–9. PMID 1249369. doi:10.1021/ja00422a056. 
  4. ^ Bergstrom, Donald E.; Ogawa, Mark K. (1978). "C-5 substituted pyrimidine nucleosides. 2. Synthesis via olefin coupling to organopalladium intermediates derived from uridine and 2'-deoxyuridine". Journal of the American Chemical Society. 100 (26): 8106–8112. ISSN 0002-7863. doi:10.1021/ja00494a014.