At the 1868 general election he was elected on his first attempt a Member of Parliament (MP) for the two-seat constituency of Preston in Lancashire. He was re-elected in the 1874 and in 1880 general elections, and held the seat until he died in office in 1881, aged 59. The resulting by-election in Preston was held on 23 May 1881, and won by the Conservative candidate William Ecroyd.
Hermon's last recorded contribution to debates in the House of Commons was eight days before his death, aged 59, on 28 April 1881, when he asked Prime Minister Gladstone a sceptical question about the proposed commercial treaty with France.
Hermon's only daughter was Frances Caroline Hermon (died 1929), who was married in 1877 to Robert Trotter Hodge (1851–1937), who later became MP for Accrington and other constituencies. After being made a baronet in 1902, Hodge changed his surname to Hermon-Hodge in honour of his wife's family, and was later ennobled as Baron Wyfold.
- "Historical list of MPs: Constituencies beginning with "P" (part 2 )". Leigh Rayment's peerage pages. Retrieved 19 November 2009.
- Sherwood, Jennifer; Pevsner, Nikolaus (1974). Oxfordshire. The Buildings of England. Harmondsworth: Penguin Books. p. 738. ISBN 0-14-071045-0.
- Craig, F. W. S. (1989) . British parliamentary election results 1832–1885 (2nd ed.). Chichester: Parliamentary Research Services. pp. 248–249. ISBN 0-900178-26-4.
- "House of Commons Debates 28 April 1881 vol 260 columns 1313-4". Hansard 1803-2005. Retrieved 19 November 2009.
- Lundy, Darryl. "Frances Caroline Hermon". ThePeerage.com. Retrieved 19 November 2009.[unreliable source]
- Hansard 1803–2005: contributions in Parliament by Edward Hermon
|Parliament of the United Kingdom|
Hon. Frederick Stanley and
Sir Thomas Hesketh
|Member of Parliament for Preston
1868 – 1881
With: Sir Thomas Hesketh to 1872
John Holker from 1872
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