Steuermann studied piano with Vilém Kurz at the Lemberg Conservatory and Ferruccio Busoni in Berlin, and studied composition with Engelbert Humperdinck and Arnold Schoenberg. He played the piano part in the first performance of Schoenberg's Pierrot Lunaire and premiered his Piano Concerto. He continued his association with Schoenberg as a pianist for the composer's Society for Private Musical Performances in Vienna, and made an arrangement for piano trio of Schoenberg's Verklärte Nacht. He performed in the radio premiere of Schoenberg's "Ode to Napoleon Bonaparte" with the New York Philharmonic under Artur Rodziński on November 26, 1944. In 1952 he was awarded the Schoenberg Medal by the International Society for Contemporary Music. He taught at the Internationale Ferienkurse für Neue Musik at Darmstadt.
In the United States, where he emigrated in 1938, he was famed for his Beethoven recitals of the 1950s and was a distinguished teacher, teaching at the Juilliard School from 1952 to 1964. In America he was known as Edward Steuermann. Among the prominent performers who studied with Steuermann are Alfred Brendel, Jakob Gimpel, Moura Lympany, Avraham Sternklar and Russell Sherman. He also taught philosopher Theodor W. Adorno, composer Gunther Schuller and theorists Edward T. Cone and David Lewin.
In 1964 he died of leukemia. In 1989, the University of Nebraska Press published a collection of Steuermann's writings entitled, The Not Quite Innocent Bystander: Writings of Edward Steuermann (ISBN 0803241917). The book was co-edited by Clara Steuermann, David H. Porter and Gunther Schuller.