Effect of spaceflight on the human body
Venturing into the environment of space can have negative effects on the human body. Significant adverse effects of long-term weightlessness include muscle atrophy and deterioration of the skeleton (spaceflight osteopenia). Other significant effects include a slowing of cardiovascular system functions, decreased production of red blood cells, balance disorders, eyesight disorders and changes in the immune system. Additional symptoms include fluid redistribution (causing the "moon-face" appearance typical in pictures of astronauts experiencing weightlessness), loss of body mass, nasal congestion, sleep disturbance, and excess flatulence.
The engineering problems associated with leaving Earth and developing space propulsion systems have been examined for over a century, and millions of hours of research have been spent on them. In recent years there has been an increase in research on the issue of how humans can survive and work in space for extended and possibly indefinite periods of time. This question requires input from the physical and biological sciences and has now become the greatest challenge (other than funding) facing human space exploration. A fundamental step in overcoming this challenge is trying to understand the effects and impact of long-term space travel on the human body.
On 12 April 2019, NASA reported medical results, from the Astronaut Twin Study, where one astronaut twin spent a year in space on the International Space Station, while the other twin spent the year on Earth, which demonstrated several long-lasting changes, including those related to alterations in DNA and cognition, when one twin was compared with the other.
In November 2019, researchers reported that astronauts experienced serious blood flow and clot problems while on board the International Space Station, based on a six-month study of 11 healthy astronauts. The results may influence long-term spaceflight, including a mission to the planet Mars, according to the researchers.
Many of the environmental conditions experienced by humans during spaceflight are very different from those in which humans evolved; however, technology such as that offered by a spaceship or spacesuit is able to shield people from the harshest conditions. The immediate needs for breathable air and drinkable water are addressed by a life support system, a group of devices that allow human beings to survive in outer space. The life support system supplies air, water and food. It must also maintain temperature and pressure within acceptable limits and deal with the body's waste products. Shielding against harmful external influences such as radiation and micro-meteorites is also necessary.
Some hazards are difficult to mitigate, such as weightlessness, also defined as a microgravity environment. Living in this type of environment impacts the body in three important ways: loss of proprioception, changes in fluid distribution, and deterioration of the musculoskeletal system.
On November 2, 2017, scientists reported that significant changes in the position and structure of the brain have been found in astronauts who have taken trips in space, based on MRI studies. Astronauts who took longer space trips were associated with greater brain changes.
In October 2018, NASA-funded researchers found that lengthy journeys into outer space, including travel to the planet Mars, may substantially damage the gastrointestinal tissues of astronauts. The studies support earlier work that found such journeys could significantly damage the brains of astronauts, and age them prematurely.
Space medicine is a developing medical practice that studies the health of astronauts living in outer space. The main purpose of this academic pursuit is to discover how well and for how long people can survive the extreme conditions in space, and how fast they can re-adapt to the Earth's environment after returning from space. Space medicine also seeks to develop preventive and palliative measures to ease the suffering caused by living in an environment to which humans are not well adapted.
Ascent and re-entry
During takeoff and re-entry space travelers can experience several times normal gravity. An untrained person can usually withstand about 3g, but can blackout at 4 to 6g. G-force in the vertical direction is more difficult to tolerate than a force perpendicular to the spine because blood flows away from the brain and eyes. First the person experiences a temporary loss of vision and then at higher g-forces loses consciousness. G-force training and a G-suit which constricts the body to keep more blood in the head can mitigate the effects. Most spacecraft are designed to keep g-forces within comfortable limits.
The environment of space is lethal without appropriate protection: the greatest threat in the vacuum of space derives from the lack of oxygen and pressure, although temperature and radiation also pose risks. The effects of space exposure can result in ebullism, hypoxia, hypocapnia, and decompression sickness. In addition to these, there is also cellular mutation and destruction from high energy photons and sub-atomic particles that are present in the surroundings. Decompression is a serious concern during the extra-vehicular activities (EVAs) of astronauts. Current EMU designs take this and other issues into consideration, and have evolved over time. A key challenge has been the competing interests of increasing astronaut mobility (which is reduced by high-pressure EMUs, analogous to the difficulty of deforming an inflated balloon relative to a deflated one) and minimising decompression risk. Investigators have considered pressurizing a separate head unit to the regular 71 kPa (10.3 psi) cabin pressure as opposed to the current whole-EMU pressure of 29.6 kPa (4.3 psi). In such a design, pressurization of the torso could be achieved mechanically, avoiding mobility reduction associated with pneumatic pressurization.
Human physiology is adapted to living within the atmosphere of Earth, and a certain amount of oxygen is required in the air we breathe. If the body does not get enough oxygen, then the astronaut is at risk of becoming unconscious and dying from hypoxia. In the vacuum of space, gas exchange in the lungs continues as normal but results in the removal of all gases, including oxygen, from the bloodstream. After 9 to 12 seconds, the deoxygenated blood reaches the brain, and it results in the loss of consciousness. Exposure to vacuum for up to 30 seconds is unlikely to cause permanent physical damage. Animal experiments show that rapid and complete recovery is normal for exposures shorter than 90 seconds, while longer full-body exposures are fatal and resuscitation has never been successful. There is only a limited amount of data available from human accidents, but it is consistent with animal data. Limbs may be exposed for much longer if breathing is not impaired.
In December 1966, aerospace engineer and test subject Jim LeBlanc of NASA was participating in a test to see how well a pressurized space suit prototype would perform in vacuum conditions. To simulate the effects of space, NASA constructed a massive vacuum chamber from which all air could be pumped. At some point during the test, LeBlanc's pressurization hose became detached from the space suit. Even though this caused his suit pressure to drop from 3.8 psi (26.2 kPa) to 0.1 psi (0.7 kPa) in less than 10 seconds, LeBlanc remained conscious for about 14 seconds before losing consciousness due to hypoxia; the much lower pressure outside the body causes rapid de-oxygenation of the blood. "As I stumbled backwards, I could feel the saliva on my tongue starting to bubble just before I went unconscious and that's the last thing I remember," recalls LeBlanc. The chamber was rapidly pressurized and LeBlanc was given emergency oxygen 25 seconds later. He recovered almost immediately with just an earache and no permanent damage.
Another effect from a vacuum is a condition called ebullism which results from the formation of bubbles in body fluids due to reduced ambient pressure, the steam may bloat the body to twice its normal size and slow circulation, but tissues are elastic and porous enough to prevent rupture. Technically, ebullism is considered to begin at an elevation of around 19 kilometres (12 mi) or pressures less than 6.3 kPa (47 mm Hg), known as the Armstrong limit. Experiments with other animals have revealed an array of symptoms that could also apply to humans. The least severe of these is the freezing of bodily secretions due to evaporative cooling. Severe symptoms, such as loss of oxygen in tissue, followed by circulatory failure and flaccid paralysis would occur in about 30 seconds. The lungs also collapse in this process, but will continue to release water vapour leading to cooling and ice formation in the respiratory tract. A rough estimate is that a human will have about 90 seconds to be recompressed, after which death may be unavoidable. Swelling from ebullism can be reduced by containment in a flight suit which are necessary to prevent ebullism above 19 km. During the Space Shuttle program astronauts wore a fitted elastic garment called a Crew Altitude Protection Suit (CAPS) which prevented ebullism at pressures as low as 2 kPa (15 mm Hg).
The only humans known to have died of exposure to vacuum in space are the three crew-members of the Soyuz 11 spacecraft; Vladislav Volkov, Georgi Dobrovolski, and Viktor Patsayev. During preparations for re-entry from orbit on June 30, 1971, a pressure-equalisation valve in the spacecraft's descent module unexpectedly opened at an altitude of 168 kilometres (551,000 ft), causing rapid depressurisation and the subsequent death of the entire crew.
In a vacuum, there is no medium for removing heat from the body by conduction or convection. Loss of heat is by radiation from the 310 K temperature of a person to the 3 K of outer space. This is a slow process, especially in a clothed person, so there is no danger of immediately freezing. Rapid evaporative cooling of skin moisture in a vacuum may create frost, particularly in the mouth, but this is not a significant hazard.
Exposure to the intense radiation of direct, unfiltered sunlight would lead to local heating, though that would likely be well distributed by the body's conductivity and blood circulation. Other solar radiation, particularly ultraviolet rays, however, may cause severe sunburn.
Without the protection of Earth's atmosphere and magnetosphere astronauts are exposed to high levels of radiation. High levels of radiation damage lymphocytes, cells heavily involved in maintaining the immune system; this damage contributes to the lowered immunity experienced by astronauts. Radiation has also recently been linked to a higher incidence of cataracts in astronauts. Outside the protection of low Earth orbit, galactic cosmic rays present further challenges to human spaceflight, as the health threat from cosmic rays significantly increases the chances of cancer over a decade or more of exposure. A NASA-supported study reported that radiation may harm the brain of astronauts and accelerate the onset of Alzheimer's disease. Solar flare events (though rare) can give a fatal radiation dose in minutes. It is thought that protective shielding and protective drugs may ultimately lower the risks to an acceptable level.
Crew living on the International Space Station (ISS) are partially protected from the space environment by Earth's magnetic field, as the magnetosphere deflects solar wind around the earth and the ISS. Nevertheless, solar flares are powerful enough to warp and penetrate the magnetic defences, and so are still a hazard to the crew. The crew of Expedition 10 took shelter as a precaution in 2005 in a more heavily shielded part of the station designed for this purpose. However, beyond the limited protection of Earth's magnetosphere, interplanetary human missions are much more vulnerable. Lawrence Townsend of the University of Tennessee and others have studied the most powerful solar flare ever recorded. Radiation doses astronauts would receive from a flare of this magnitude could cause acute radiation sickness and possibly even death.
There is scientific concern that extended spaceflight might slow down the body's ability to protect itself against diseases. Radiation can penetrate living tissue and cause both short and long-term damage to the bone marrow stem cells which create the blood and immune systems. In particular, it causes 'chromosomal aberrations' in lymphocytes. As these cells are central to the immune system, any damage weakens the immune system, which means that in addition to increased vulnerability to new exposures, viruses already present in the body—which would normally be suppressed—become active. In space, T-cells (a form of lymphocyte) are less able to reproduce properly, and the T-cells that do reproduce are less able to fight off infection. Over time immunodeficiency results in the rapid spread of infection among crew members, especially in the confined areas of space flight systems.
On 31 May 2013, The NASA scientists reported that a possible human mission to Mars may involve a great radiation risk based on the amount of energetic particle radiation detected by the RAD on the Mars Science Laboratory while traveling from the Earth to Mars in 2011–2012.
In September 2017, NASA reported radiation levels on the surface of the planet Mars were temporarily doubled, and were associated with an aurora 25-times brighter than any observed earlier, due to a massive, and unexpected, solar storm in the middle of the month.
Following the advent of space stations that can be inhabited for long periods of time, exposure to weightlessness has been demonstrated to have some deleterious effects on human health. Humans are well-adapted to the physical conditions at the surface of the earth, and so in response to weightlessness, various physiological systems begin to change, and in some cases, atrophy. Though these changes are usually temporary, some do have a long-term impact on human health.
Short-term exposure to microgravity causes space adaptation syndrome, self-limiting nausea caused by derangement of the vestibular system. Long-term exposure causes multiple health problems, one of the most significant being loss of bone and muscle mass. Over time these deconditioning effects can impair astronauts' performance, increase their risk of injury, reduce their aerobic capacity, and slow down their cardiovascular system. As the human body consists mostly of fluids, gravity tends to force them into the lower half of the body, and our bodies have many systems to balance this situation. When released from the pull of gravity, these systems continue to work, causing a general redistribution of fluids into the upper half of the body. This is the cause of the round-faced 'puffiness' seen in astronauts. Redistributing fluids around the body itself causes balance disorders, distorted vision, and a loss of taste and smell.
A 2006 Space Shuttle experiment found that Salmonella typhimurium, a bacterium that can cause food poisoning, became more virulent when cultivated in space. On April 29, 2013, scientists in Rensselaer Polytechnic Institute, funded by NASA, reported that, during spaceflight on the International Space Station, microbes seem to adapt to the space environment in ways "not observed on Earth" and in ways that "can lead to increases in growth and virulence". More recently, in 2017, bacteria were found to be more resistant to antibiotics and to thrive in the near-weightlessness of space. Microorganisms have been observed to survive the vacuum of outer space.
The most common problem experienced by humans in the initial hours of weightlessness is known as space adaptation syndrome or SAS, commonly referred to as space sickness. It is related to motion sickness, and arises as the vestibular system adapts to weightlessness. Symptoms of SAS include nausea and vomiting, vertigo, headaches, lethargy, and overall malaise. The first case of SAS was reported by cosmonaut Gherman Titov in 1961. Since then, roughly 45% of all people who have flown in space have suffered from this condition.
Bone and muscle deterioration
A major effect of long-term weightlessness involves the loss of bone and muscle mass. Without the effects of gravity, skeletal muscle is no longer required to maintain posture and the muscle groups used in moving around in a weightless environment differ from those required in terrestrial locomotion. In a weightless environment, astronauts put almost no weight on the back muscles or leg muscles used for standing up. Those muscles then start to weaken and eventually get smaller. Consequently, some muscles atrophy rapidly, and without regular exercise astronauts can lose up to 20% of their muscle mass in just 5 to 11 days. The types of muscle fibre prominent in muscles also change. Slow-twitch endurance fibres used to maintain posture are replaced by fast-twitch rapidly contracting fibres that are insufficient for any heavy labour. Advances in research on exercise, hormone supplements, and medication may help maintain muscle and body mass.
Bone metabolism also changes. Normally, bone is laid down in the direction of mechanical stress. However, in a microgravity environment, there is very little mechanical stress. This results in a loss of bone tissue approximately 1.5% per month especially from the lower vertebrae, hip, and femur. Due to microgravity and the decreased load on the bones, there is a rapid increase in bone loss, from 3% cortical bone loss per decade to about 1% every month the body is exposed to microgravity, for an otherwise healthy adult. The rapid change in bone density is dramatic, making bones frail and resulting in symptoms that resemble those of osteoporosis. On Earth, the bones are constantly being shed and regenerated through a well-balanced system which involves signaling of osteoblasts and osteoclasts. These systems are coupled, so that whenever bone is broken down, newly formed layers take its place—neither should happen without the other, in a healthy adult. In space, however, there is an increase in osteoclast activity due to microgravity. This is a problem because osteoclasts break down the bones into minerals that are reabsorbed by the body. Osteoblasts are not consecutively active with the osteoclasts, causing the bone to be constantly diminished with no recovery. This increase in osteoclasts activity has been seen particularly in the pelvic region because this is the region that carries the biggest load with gravity present. A study demonstrated that in healthy mice, osteoclasts appearance increased by 197%, accompanied by a down-regulation of osteoblasts and growth factors that are known to help with the formation of new bone, after only sixteen days of exposure to microgravity. Elevated blood calcium levels from the lost bone result in dangerous calcification of soft tissues and potential kidney stone formation. It is still unknown whether bone recovers completely. Unlike people with osteoporosis, astronauts eventually regain their bone density. After a 3–4 month trip into space, it takes about 2–3 years to regain lost bone density. New techniques are being developed to help astronauts recover faster. Research on diet, exercise, and medication may hold the potential to aid the process of growing new bone.
To prevent some of these adverse physiological effects, the ISS is equipped with two treadmills (including the COLBERT), and the aRED (advanced Resistive Exercise Device), which enable various weight-lifting exercises which add muscle but do nothing for bone density, and a stationary bicycle; each astronaut spends at least two hours per day exercising on the equipment. Astronauts use bungee cords to strap themselves to the treadmill. Astronauts subject to long periods of weightlessness wear pants with elastic bands attached between waistband and cuffs to compress the leg bones and reduce osteopenia.
Currently, NASA is using advanced computational tools to understand how to best counteract the bone and muscle atrophy experienced by astronauts in microgravity environments for prolonged periods of time. The Human Research Program's Human Health Countermeasures Element chartered the Digital Astronaut Project to investigate targeted questions about exercise countermeasure regimes. NASA is focusing on integrating a model of the advanced Resistive Exercise Device (ARED) currently on board the International Space Station with OpenSim musculoskeletal models of humans exercising with the device. The goal of this work is to use inverse dynamics to estimate joint torques and muscle forces resulting from using the ARED, and thus more accurately prescribe exercise regimens for the astronauts. These joint torques and muscle forces could be used in conjunction with more fundamental computational simulations of bone remodeling and muscle adaptation in order to more completely model the end effects of such countermeasures, and determine whether a proposed exercise regime would be sufficient to sustain astronaut musculoskeletal health.
In space, astronauts lose fluid volume—including up to 22% of their blood volume. Because it has less blood to pump, the heart will atrophy. A weakened heart results in low blood pressure and can produce a problem with "orthostatic tolerance", or the body's ability to send enough oxygen to the brain without the astronaut's fainting or becoming dizzy. "Under the effects of the earth's gravity, blood and other body fluids are pulled towards the lower body. When gravity is taken away or reduced during space exploration, the blood tends to collect in the upper body instead, resulting in facial edema and other unwelcome side effects. Upon return to earth, the blood begins to pool in the lower extremities again, resulting in orthostatic hypotension."
Disruption of senses
In 2013 NASA published a study that found changes to the eyes and eyesight of monkeys with spaceflights longer than 6 months. Noted changes included a flattening of the eyeball and changes to the retina. Space traveler's eye-sight can become blurry after too much time in space. Another effect is known as cosmic ray visual phenomena.
...[a] NASA survey of 300 male and female astronauts, about 23 percent of short-flight and 49 percent of long-flight astronauts said they had experienced problems with both near and distance vision during their missions. Again, for some people vision problems persisted for years afterward.— NASA
Since dust can not settle in zero gravity, small pieces of dead skin or metal can get in the eye, causing irritation and increasing the risk of infection.
Because weightlessness increases the amount of fluid in the upper part of the body, astronauts experience increased intracranial pressure. This appears to increase pressure on the backs of the eyeballs, affecting their shape and slightly crushing the optic nerve. This effect was noticed in 2012 in a study using MRI scans of astronauts who had returned to Earth following at least one month in space. Such eyesight problems could be a major concern for future deep space flight missions, including a crewed mission to the planet Mars.
If indeed elevated intracranial pressure is the cause, artificial gravity might present one solution, as it would for many human health risks in space. However, such artificial gravitational systems have yet to be proven. More, even with sophisticated artificial gravity, a state of relative microgravity may remain, the risks of which remain unknown. 
One effect of weightlessness on humans is that some astronauts report a change in their sense of taste when in space. Some astronauts find that their food is bland, others find that their favorite foods no longer taste as good (one who enjoyed coffee disliked the taste so much on a mission that he stopped drinking it after returning to Earth); some astronauts enjoy eating certain foods that they would not normally eat, and some experience no change whatsoever. Multiple tests have not identified the cause, and several theories have been suggested, including food degradation, and psychological changes such as boredom. Astronauts often choose strong-tasting food to combat the loss of taste.
Additional physiological effects
Within one month the human skeleton fully extends in weightlessness, causing height to increase by an inch. After two months, calluses on the bottoms of feet molt and fall off from lack of use, leaving soft new skin. Tops of feet become, by contrast, raw and painfully sensitive, as they rub against the handrails feet are hooked into for stability. Tears cannot be shed while crying, as they stick together into a ball. In microgravity odors quickly permeate the environment, and NASA found in a test that the smell of cream sherry triggered the gag reflex. Various other physical discomforts such as back and abdominal pain are common because of the readjustment to gravity, where in space there was no gravity and these muscles could freely stretch. These may be part of the asthenization syndrome reported by cosmonauts living in space over an extended period of time, but regarded as anecdotal by astronauts. Fatigue, listlessness, and psychosomatic worries are also part of the syndrome. The data is inconclusive; however, the syndrome does appear to exist as a manifestation of the internal and external stress crews in space must face.
The psychological effects of living in space have not been clearly analyzed but analogies on Earth do exist, such as Arctic research stations and submarines. The enormous stress on the crew, coupled with the body adapting to other environmental changes, can result in anxiety, insomnia and depression.
There has been considerable evidence that psychosocial stressors are among the most important impediments to optimal crew morale and performance. Cosmonaut Valery Ryumin, twice Hero of the Soviet Union, quotes this passage from The Handbook of Hymen by O. Henry in his autobiographical book about the Salyut 6 mission: "If you want to instigate the art of manslaughter just shut two men up in an eighteen by twenty-foot cabin for a month. Human nature won't stand it."
NASA's interest in psychological stress caused by space travel, initially studied when their crewed missions began, was rekindled when astronauts joined cosmonauts on the Russian space station Mir. Common sources of stress in early American missions included maintaining high performance while under public scrutiny, as well as isolation from peers and family. On the ISS, the latter is still often a cause of stress, such as when NASA Astronaut Daniel Tani's mother died in a car accident, and when Michael Fincke was forced to miss the birth of his second child.
The amount and quality of sleep experienced in space is poor due to highly variable light and dark cycles on flight decks and poor illumination during daytime hours in the spacecraft. Even the habit of looking out of the window before retiring can send the wrong messages to the brain, resulting in poor sleep patterns. These disturbances in circadian rhythm have profound effects on the neurobehavioural responses of the crew and aggravate the psychological stresses they already experience (see Fatigue and sleep loss during spaceflight for more information). Sleep is disturbed on the ISS regularly due to mission demands, such as the scheduling of incoming or departing space vehicles. Sound levels in the station are unavoidably high because the atmosphere is unable to thermosiphon; fans are required at all times to allow processing of the atmosphere, which would stagnate in the freefall (zero-g) environment. Fifty percent of space shuttle astronauts took sleeping pills and still got 2 hours less sleep each night in space than they did on the ground. NASA is researching two areas which may provide the keys to a better night's sleep, as improved sleep decreases fatigue and increases daytime productivity. A variety of methods for combating this phenomenon are constantly under discussion.
Duration of space travel
A study of the longest spaceflight concluded that the first three weeks represent a critical period where attention is adversely affected because of the demand to adjust to the extreme change of environment. While Skylab's three crews remained in space 1, 2, and 3 months respectively, long-term crews on Salyut 6, Salyut 7, and the ISS remain about 5–6 months, while MIR expeditions often lasted longer. The ISS working environment includes further stress caused by living and working in cramped conditions with people from very different cultures who speak different languages. First-generation space stations had crews who spoke a single language, while 2nd and 3rd generation stations have crews from many cultures who speak many languages. The ISS is unique because visitors are not classed automatically into 'host' or 'guest' categories as with previous stations and spacecraft, and may not suffer from feelings of isolation in the same way.
The sum of human experience has resulted in the accumulation of 58 solar years in space and a much better understanding of how the human body adapts. In the future, industrialisation of space and exploration of inner and outer planets will require humans to endure longer and longer periods in space. The majority of current data comes from missions of short duration and so some of the long-term physiological effects of living in space are still unknown. A round trip to Mars with current technology is estimated to involve at least 18 months in transit alone. Knowing how the human body reacts to such time periods in space is a vital part of the preparation for such journeys. On-board medical facilities need to be adequate for coping with any type of trauma or emergency as well as contain a huge variety of diagnostic and medical instruments in order to keep a crew healthy over a long period of time, as these will be the only facilities available on board a spacecraft for coping not only with trauma but also with the adaptive responses of the human body in space.
At the moment only rigorously tested humans have experienced the conditions of space. If off-world colonization someday begins, many types of people will be exposed to these dangers, and the effects on the very young are completely unknown. On October 29, 1998, John Glenn, one of the original Mercury 7, returned to space at the age of 77. His space flight, which lasted 9 days, provided NASA with important information about the effects of space flight on older people. Factors such as nutritional requirements and physical environments which have so far not been examined will become important. Overall, there is little data on the manifold effects of living in space, and this makes attempts toward mitigating the risks during a lengthy space habitation difficult. Testbeds such as the ISS are currently being utilized to research some of these risks.
The environment of space is still largely unknown, and there will likely be as-yet-unknown hazards. Meanwhile, future technologies such as artificial gravity and more complex bioregenerative life support systems may someday be capable of mitigating some risks.
- Fatigue and sleep loss during spaceflight
- Food systems on space exploration missions
- Ionizing radiation#Spaceflight
- Intervertebral disc damage and spaceflight
- Locomotion in space
- Mars Analog Habitats
- Medical treatment during spaceflight
- Overview effect
- Reduced muscle mass, strength and performance in space
- Renal stone formation in space
- Environmental control system
- Space colonization
- Spaceflight radiation carcinogenesis
- Team composition and cohesion in spaceflight missions
- Visual impairment due to intracranial pressure
- Chang, Kenneth (27 January 2014). "Beings Not Made for Space". The New York Times. Retrieved 27 January 2014.
- Kanas, Nick; Manzey, Dietrich (2008), "Basic Issues of Human Adaptation to Space Flight", Space Psychology and Psychiatry, Space Technology Library, 22: 15–48, Bibcode:2008spp..book.....K, doi:10.1007/978-1-4020-6770-9_2, ISBN 978-1-4020-6769-3
- Neergard, Lauran; Birenstein, Seth (15 February 2019). "Year in space put US astronaut's disease defenses on alert". AP News. Retrieved 18 February 2019.
- "Health and Fitness". Space Future. Retrieved 2012-05-10.
- Toyohiro Akiyama (April 14, 1993). "The Pleasure of Spaceflight". Journal of Space Technology and Science. 9 (1): 21–23. Retrieved 2012-05-10.
- Dunn, Marcia (October 29, 2015). "Report: NASA needs better handle on health hazards for Mars". AP News. Retrieved October 30, 2015.
- Staff (October 29, 2015). "NASA's Efforts to Manage Health and Human Performance Risks for Space Exploration (IG-16-003)" (PDF). NASA. Retrieved October 29, 2015.
- Zimmer, Carl (12 April 2019). "Scott Kelly Spent a Year in Orbit. His Body Is Not Quite the Same". The New York Times. Retrieved 12 April 2019.
- Garrett-Bakeman, Francine E.; et al. (12 April 2019). "The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight". Science. 364 (6436). doi:10.1126/science.aau8650 (inactive 2021-01-14). PMC 7580864. PMID 30975860. Retrieved 12 April 2019.CS1 maint: DOI inactive as of January 2021 (link)
- Strickland, Ashley (15 November 2019). "Astronauts experienced reverse blood flow and blood clots on the space station, study says". CNN News. Retrieved 16 November 2019.
- Marshall-Goebel, Karina; et al. (13 November 2019). "Assessment of Jugular Venous Blood Flow Stasis and Thrombosis During Spaceflight". JAMA Network Open. 2 (11): e1915011. doi:10.1001/jamanetworkopen.2019.15011. PMC 6902784. PMID 31722025.
- "Breathing Easy on the Space Station". NASA. Archived from the original on 2008-09-21. Retrieved 2012-04-26.
- Roberts, Donna R.; et al. (2 November 2017). "Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI". New England Journal of Medicine. 377 (18): 1746–1753. doi:10.1056/NEJMoa1705129. PMID 29091569. S2CID 205102116.
- Foley, Katherine Ellen (3 November 2017). "Astronauts who take long trips to space return with brains that have floated to the top of their skulls". Quartz. Retrieved 3 November 2017.
- Griffin, Andrew (1 October 2018). "Travelling to Mars and deep into space could kill astronauts by destroying their guts, finds Nasa-funded study". The Independent. Retrieved 2 October 2018.
- "Dormant viruses activate during spaceflight -- NASA investigates". EurekAlert!. 15 March 2019. Retrieved 16 March 2019.
- Pilmanis, Andrew; William Sears (December 2003). "Physiological hazards of flight at high altitude". The Lancet. 362: s16–s17. doi:10.1016/S0140-6736(03)15059-3. PMID 14698113. S2CID 8210206.
- Conkin, Johnny (January 2001). "Evidence-Based Approach to the Analysis of Serious Decompression Sickness With Application to EVA Astronauts" (PDF).Archived 2006-10-05 at the Wayback Machine NASA TP-2001-210196. Retrieved 2012-09-23.
- Jordan N.C., Saleh J.H., Newman D.J. (2005). "The Extravehicular Mobility Unit: case study in requirements evolution". 13th IEEE International Conference on Requirements Engineering (RE'05): 434–438. doi:10.1109/RE.2005.69. ISBN 0-7695-2425-7. S2CID 9850178.CS1 maint: multiple names: authors list (link) (subscription required)
- Jordan, Nicole C.; Saleh, Joseph H.; Newman, Dava J. (2006). "The extravehicular mobility unit: A review of environment, requirements, and design changes in the US spacesuit". Acta Astronautica. 59 (12): 1135–1145. Bibcode:2006AcAau..59.1135J. doi:10.1016/j.actaastro.2006.04.014.
- Gorguinpour, Camron et. al (2001), LPI "Advanced Two-System Space Suit". University of California, Berkeley CB-1106. Retrieved 2012-09-23. 95 KB
- for reference, the atmospheric pressure at sea level is 101.4 kPa, equal to 14.7 psi – Britannica
- Landis, Geoffrey A. (7 August 2007). "Human Exposure to Vacuum". www.geoffreylandis.com. Archived from the original on 2009-07-21. Retrieved 2012-04-25.
- Author/s not stated (3 June 1997). "Ask an Astrophysicist: Human Body in a Vacuum". NASA(Goddard Space Flight Centre). Retrieved 2012-04-25.
- Cooke, J.P,; Bancroft, R.W. (1966). "Some Cardiovascular Responses in Anesthetized Dogs During Repeated Decompressions to a Near-Vacuum". Aerospace Medicine. 37: 1148–52. PMID 5297100.CS1 maint: uses authors parameter (link)
- Greene, Nick (6 October 2019). "What Happens To The Human Body In A Vacuum?". ThoughtCo. Retrieved 2012-04-25.
- Harding, Richard M. (1989). Survival in Space: Medical Problems of Manned Spaceflight. London: Routledge. ISBN 978-0-415-00253-0.
- Rose, Brent (17 November 2014). "Inside the Chamber Where NASA Recreates Space on Earth". Gizmodo. Retrieved 8 April 2018.
- Pant, Anupum (23 May 2015). "The Only Person who Survived in Vacuum". AweSci. Retrieved 8 April 2018.
- Merryl, Azriel (28 November 2012). "Jim LeBlanc Survives Early Spacesuit Vacuum Test Gone Wrong". Space Safety Magazine. Retrieved 8 April 2018.
- Thompson, Avery (2 December 2016). "The Time a NASA Experiment Gone Wrong Almost Killed Someone". Popular Mechanics. Retrieved 8 April 2018.
In a giant chamber with no air, all sorts of bad things can happen.
- Oakes, Troy (8 March 2015). "What Happens When a Man Is Exposed to the Vacuum Conditions of Space?". Vision Times. Retrieved 8 April 2018.
- Billings, Charles E. (1973). "Chapter 1) Barometric Pressure". In Parker, James F.; West, Vita R. (eds.). Bioastronautics Data Book (Second ed.). NASA. p. 5. hdl:2060/19730006364. NASA SP-3006. 942 pages.
- Billings, Charles E. (1973). "Chapter 1) Barometric Pressure" (PDF). In James F.; West, Vita R (eds.). Bioastronautics Data Book (Second ed.). NASA. pp. 2–5. NASA SP-3006. Retrieved 2012-09-23.
- Landis, Geoffrey (7 August 2007). "Human Exposure to Vacuum". Retrieved 2006-03-25.
- Webb, P. (1968). "The Space Activity Suit: An Elastic Leotard for Extravehicular Activity". Aerospace Medicine. 39 (4): 376–83. PMID 4872696.
- Stewart Lowan H (2007). "Emergency medicine in space". The Journal of Emergency Medicine. 32 (1): 45–54. doi:10.1016/j.jemermed.2006.05.031. PMID 17239732.
- "Science: Triumph and Tragedy of Soyuz 11". Time Magazine. July 12, 1971. (subscription required)
- "Ask a scientist. Why is space cold?". Argonne National Laboratory, Division of Educational Programs. Retrieved 2008-11-27.
- Kerr, Richard (31 May 2013). "Radiation Will Make Astronauts' Trip to Mars Even Riskier". Science. 340 (6136): 1031. Bibcode:2013Sci...340.1031K. doi:10.1126/science.340.6136.1031. PMID 23723213.
- Zeitlin, C. et al. (31 May 2013). "Measurements of Energetic Particle Radiation in Transit to Mars on the Mars Science Laboratory". Science. 340 (6136): 1080–84. Bibcode:2013Sci...340.1080Z. doi:10.1126/science.1235989. PMID 23723233. S2CID 604569.CS1 maint: uses authors parameter (link)
- Chang, Kenneth (30 May 2013). "Data Point to Radiation Risk for Travelers to Mars". The New York Times. Retrieved 31 May 2013.
- Space Radiation Hazards and the Vision for Space Exploration. NAP. 2006. doi:10.17226/11760. ISBN 978-0-309-10264-3.
- "The Right Stuff for Super Spaceships". NASA. 16 September 2002. Retrieved 2012-05-10.
- Cherry, Jonathan D.; Frost, Jeffrey L.; Lemere, Cynthia A.; Williams, Jacqueline P.; Olschowka, John A.; O'Banion, M. Kerry (2012). "Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer's Disease". PLOS ONE. 7 (12): e53275. Bibcode:2012PLoSO...753275C. doi:10.1371/journal.pone.0053275. PMC 3534034. PMID 23300905.
- Parihar, Vipan K.; et al. (2016). "Cosmic radiation exposure and persistent cognitive dysfunction". Sci. Rep. 6: 34774. Bibcode:2016NatSR...634774P. doi:10.1038/srep34774. PMC 5056393. PMID 27721383.
- "Study Shows that Space Travel is Harmful to the Brain and Could Accelerate Onset of Alzheimer's". SpaceRef. January 1, 2013. Retrieved January 7, 2013.
- Cowing, Keith (January 3, 2013). "Important Research Results NASA Is Not Talking About (Update)". NASA Watch. Retrieved January 7, 2013.
- Buckey, Jay (23 February 2006). Space Physiology. Oxford University Press USA. ISBN 978-0-19-513725-5.
- Than, Ker (23 February 2006). "Solar Flare Hits Earth and Mars". Space.com.
- "A new kind of solar storm". NASA. 10 June 2005.
- Battersby, Stephen (21 March 2005). "Superflares could kill unprotected astronauts". New Scientist.
- Gueguinou, N.; Huin-Schohn, C.; Bascove, M.; Bueb, J.-L.; Tschirhart, E.; Legrand-Frossi, C.; Frippiat, J.-P. (2009). "Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit". Journal of Leukocyte Biology. 86 (5): 1027–38. doi:10.1189/jlb.0309167. PMID 19690292. S2CID 18962181.
- Fong, Kevin (12 February 2014). "The Strange, Deadly Effects Mars Would Have on Your Body". Wired. Retrieved 12 February 2014.
- Scott, Jim (30 September 2017). "Large solar storm sparks global aurora and doubles radiation levels on the martian surface". Phys.org. Retrieved 30 September 2017.
- "Exercise Physiology and Countermeasures Project (ExPC): Keeping Astronauts Healthy in Reduced Gravity". NASA. Archived from the original on 2012-05-04. Retrieved 2012-05-11.
- Elder, Donald C. (1998). "The Human Touch: The History of the Skylab Program". In Mack, Pamela E. (ed.). From Engineering Science to Big Science: The NACA and NASA Collier Trophy Research Project Winners. The NASA History Series. NASA. SP-4219.
- Caspermeyer, Joe (23 September 2007). "Space flight shown to alter ability of bacteria to cause disease". Arizona State University. Retrieved 14 September 2017.
- Kim W, et al. (April 29, 2013). "Spaceflight Promotes Biofilm Formation by Pseudomonas aeruginosa". PLOS ONE. 8 (4): e6237. Bibcode:2013PLoSO...862437K. doi:10.1371/journal.pone.0062437. PMC 3639165. PMID 23658630.
- Dvorsky, George (13 September 2017). "Alarming Study Indicates Why Certain Bacteria Are More Resistant to Drugs in Space". Gizmodo. Retrieved 14 September 2017.
- Dose, K.; Bieger-Dose, A.; Dillmann, R.; Gill, M.; Kerz, O.; Klein, A.; Meinert, H.; Nawroth, T.; Risi, S.; Stridde, C. (1995). "ERA-experiment "space biochemistry"". Advances in Space Research. 16 (8): 119–129. Bibcode:1995AdSpR..16..119D. doi:10.1016/0273-1177(95)00280-R. PMID 11542696.
- Horneck G.; Eschweiler, U.; Reitz, G.; Wehner, J.; Willimek, R.; Strauch, K. (1995). "Biological responses to space: results of the experiment "Exobiological Unit" of ERA on EURECA I". Adv. Space Res. 16 (8): 105–18. Bibcode:1995AdSpR..16..105H. doi:10.1016/0273-1177(95)00279-N. PMID 11542695.
- "Why Do Astronauts Suffer From Space Sickness?". Science Daily. 2008-05-23.
- "Muscle Atrophy" (PDF). NASA. Retrieved 2013-08-03.
- "Space Bones". NASA. October 1, 2001. Retrieved 2012-05-12.
- O'Flaherty EJ (2000). "Modeling Normal Aging Bone Loss, with Consideration of Bone Loss in Osteoporosis". Toxicol Sci. 55 (1): 171–88. doi:10.1093/toxsci/55.1.171. PMID 10788572.
- Rodan GA (1998). "Bone Homeostasis". P Natl a Sci USA. 95 (23): 13361–62. Bibcode:1998PNAS...9513361R. doi:10.1073/pnas.95.23.13361. PMC 33917. PMID 9811806.
- Blaber E, Dvorochkin N, Lee C, Alwood JS, Yousuf R, Pianetta P, Globus RK, Burns BP, Almeida EAC (2013). "Microgravity induces pelvic bone loss through osteocloastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21". PLOS ONE. 8 (4): e61372. Bibcode:2013PLoSO...861372B. doi:10.1371/journal.pone.0061372. PMC 3630201. PMID 23637819.CS1 maint: multiple names: authors list (link)
- Schneider SM, Amonette WE, Blazine K, Bentley J, Lee SM, Loehr JA, Moore AD Jr, Rapley M, Mulder ER, Smith SM (November 2003). "Training with the International Space Station interim resistive exercise device". Medicine & Science in Sports & Exercise. 35 (11): 1935–45. doi:10.1249/01.MSS.0000093611.88198.08. PMID 14600562.
- "Daily life". ESA. 19 July 2004. Retrieved 28 October 2009.
- Mansfield, Cheryl L. (7 November 2008). "Station Prepares for Expanding Crew". NASA. Retrieved 17 September 2009.
- Coulter, Dauna (16 June 2009). "Bungee Cords Keep Astronauts Grounded While Running". NASA. Retrieved 23 August 2009.
- Kauderer, Amiko (19 August 2009). "Do Tread on Me". NASA. Retrieved August 23, 2009.
- "Digital Astronaut Simulates Human Body in Space". Space Flight Systems @ GRC: Human Research Program, ISS and Human Health Office, Digital Astronaut. NASA Glenn Research Center. 23 February 2013.
- White Ronald J., McPhee Jancy C. (2007). "The Digital Astronaut: An integrated modeling and database system for space biomedical research and operations". Acta Astronautica. 60 (4): 273–80. Bibcode:2007AcAau..60..273W. doi:10.1016/j.actaastro.2006.08.009.
- Lewandowski, B. E.; Pennline, J. A.; Stalker, A. R.; Mulugeta, L.; Myers, J. G. (April 11, 2011). "Musculoskeletal Modeling Component of the NASA Digital Astronaut Project". Cite journal requires
- Delp, Scott L.; Anderson, Frank C.; Arnold, Allison S.; Loan, Peter; Habib, Ayman; John, Chand T.; Guendelman, Eran; Thelen, Darryl G. (2007). "OpenSim: Open-Source Software to Create and Analyze Dynamic Simulations of Movement". IEEE Transactions on Biomedical Engineering. 54 (11): 1940–1950. doi:10.1109/TBME.2007.901024. ISSN 0018-9294. PMID 18018689. S2CID 535569.
- "When Space Makes You Dizzy". NASA. 2002. Archived from the original on 2009-08-26. Retrieved 2012-04-25.
- "NASA Finds that Space Flight Impacts Astronauts' Eyes and Vision". American Academy of Ophthalmology. 2013-07-10.
- Love, Shayla (9 July 2016). "The mysterious syndrome impairing astronauts' sight". The Washington Post.
- Howell, Elizabeth (3 November 2017). "Brain Changes in Space Could Be Linked to Vision Problems in Astronauts". Seeker. Retrieved 3 November 2017.
- Kluger, Jeffrey (2016). Gibbs, Nancy (ed.). A Year In Space: Inside Scott Kelly's historic mission – Is travel to Mars next?. Time Magazine. p. 44.
- Alexander, Robert; Macknik, Stephen; Martinez-Conde, Susana (2020). "Microsaccades in applied environments: Real-world applications of fixational eye movement measurements". Journal of Eye Movement Research. 12 (6). doi:10.16910/jemr.12.6.15.
- Michael, Alex P.; Marshall-Bowman, Karina (2015-06-01). "Spaceflight-Induced Intracranial Hypertension". Aerospace Medicine and Human Performance. 86 (6): 557–562. doi:10.3357/amhp.4284.2015. ISSN 2375-6314. PMID 26099128.
- Mader, T. H.; et al. (2011). "Optic Disc Edema, Globe Flattening, Choroidal Folds, and Hyperopic Shifts Observed in Astronauts after Long-duration Space Flight". Ophthalmology. 118 (10): 2058–69. doi:10.1016/j.ophtha.2011.06.021. PMID 21849212.
- Puiu, Tibi (November 9, 2011). "Astronauts' vision severely affected during long space missions". zmescience.com. Retrieved February 9, 2012.
- "Male Astronauts Return With Eye Problems (video)". CNN News. 9 February 2012. Retrieved 2012-04-25.
- Space Staff (13 March 2012). "Spaceflight Bad for Astronauts' Vision, Study Suggests". Space.com. Retrieved 14 March 2012.
- Kramer, Larry A.; et al. (13 March 2012). "Orbital and Intracranial Effects of Microgravity: Findings at 3-T MR Imaging". Radiology. 263 (3): 819–827. doi:10.1148/radiol.12111986. PMID 22416248.
- "Eye Problems Common in Astronauts". Discovery News. 13 March 2012. Retrieved 2012-04-25.
- Crew, Bec (29 November 2016). "Space Could Leave You Blind, And Scientists Say They've Finally Figured Out Why". ScienceAlert. Retrieved 2018-10-02.
- Sorensen, Kirk (January 1, 2006). A Tether-Based Variable-Gravity Research Facility Concept (PDF). NASA Marshall Space Flight Center.
- "NASAexplores 5–8: A Matter Of Taste". NASAexplores. NASAexplores. May 29, 2003. Archived from the original on January 7, 2008.
- Bourland, Charles T. (2006-04-07). "Charles T. Bourland". NASA Johnson Space Center Oral History Project (Interview). Interviewed by Ross-Nazzal, Jennifer. Retrieved 24 December 2014.
- Pettit, Don (2012-05-04). "Toe Koozies". Air & Space/Smithsonian. Retrieved May 8, 2012.
- Garber, Megan (2013-01-14). "Why You Can't Cry in Space". The Atlantic. Retrieved January 15, 2013.
- The Body in Space
- Nick Kanas, MD, Vyacheslav Salnitskiy, Vadim Gushin, MD, Daniel S. Weiss, Ellen M. Grund, MS, Christopher Flynn, MD, Olga Kozerenko, MD, Alexander Sled, MS and Charles R. Marmar, MD (November 1, 2001). "Asthenia – Does It Exist in Space?". Psychosomatic Medicine. 63 (6): 874–80. CiteSeerX 10.1.1.537.9855. doi:10.1097/00006842-200111000-00004. PMID 11719624. S2CID 20148453.CS1 maint: multiple names: authors list (link)
- Dickens, Peter (March 2017). "Astronauts at Work: The Social Relations of Space Travel". Monthly Review.
- Peter Suedfeld1; Kasia E. Wilk; Lindi Cassel. Flying with Strangers: Postmission Reflections of Multinational Space Crews.
- Ryumin, Valery A Year off of Earth: A cosmonaut's journal. (In Russian). Moscow: Molodaya Gvardia Publishing, 1987. Retrieved 01.21.2013
- "Wide Awake in Outer Space". NASA Science. 4 September 2001. Retrieved 9 September 2013.
- Dietrich Manzey; Bernd Lorenz; Valeri Poljakov (1998). "Mental performance in extreme environments: results from a performance monitoring study during a 438-day spaceflight". Ergonomics. 41 (4): 537–559. doi:10.1080/001401398186991. PMID 9557591. S2CID 953726.
- Nasa Report: Space Travel 'Inherently Hazardous' to Human Health. Leonard David. 2001
- Space Physiology and Medicine. Third edition. A. E. Nicogossian, C. L. Huntoon and S. L. Pool. Lea & Febiger, 1993.
- L.-F. Zhang. Vascular adaptation to microgravity: What have we learned?. Journal of Applied Physiology. 91(6) (pp 2415–2430), 2001.
- G. Carmeliet, Vico. L, Bouillon R. Critical Reviews in Eukaryotic Gene Expression. Vol 11(1–3) (pp 131–144), 2001.
- Cucinotta, Francis A.; Schimmerling, Walter; Wilson, John W.; Peterson, Leif E.; Badhwar, Gautam D.; Saganti, Premkumar B.; Dicello, John F. (2001). "Space Radiation Cancer Risks and Uncertainties for Mars Missions". Radiation Research. 156 (5): 682–688. Bibcode:2001RadR..156..682C. doi:10.1667/0033-7587(2001)156[0682:SRCRAU]2.0.CO;2. ISSN 0033-7587. PMID 11604093.
- Cucinotta, F. A.; Manuel, F. K.; Jones, J.; Iszard, G.; Murrey, J.; Djojonegro, B.; Wear, M. (2001). "Space Radiation and Cataracts in Astronauts". Radiation Research. 156 (5): 460–466. Bibcode:2001RadR..156..460C. doi:10.1667/0033-7587(2001)156[0460:SRACIA]2.0.CO;2. ISSN 0033-7587. PMID 11604058.
- Styf, Jorma R. MD; Hutchinson, Karen BS; Carlsson, Sven G. PhD, and; Hargens, Alan R. Ph.D. Depression, Mood State, and Back Pain During
- Altitude Decompression Sickness Susceptibility, MacPherson, G; Aviation, Space, and Environmental Medicine, Volume 78, Number 6, June 2007, pp. 630–631(2)
- John-Baptiste A, Cook T, Straus S, Naglie G, Gray G, Tomlinson G, Krahn M (April 2006). "Decision analysis in aerospace medicine: costs and benefits of a hyperbaric facility in space". Aviation, Space, and Environmental Medicine. 77 (4): 434–43. PMID 16676656.
- DeGroot DW, Devine JA, Fulco CS (September 2003). "Incidence of adverse reactions from 23,000 exposures to simulated terrestrial altitudes up to 8900 m". Aviation, Space, and Environmental Medicine. 74 (9): 994–7. PMID 14503681.