Ei-ichi Negishi

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Ei-ichi Negishi
Nobel Prize 2010-Press Conference KVA-DSC 7397.jpg
Negishi in 2010
Native name 根岸英一
Born (1935-07-14) July 14, 1935 (age 82)
Shinkyō, Manchukuo (now Changchun, China)
Residence United States
Nationality Japanese
Citizenship Japan[1]
Alma mater University of Tokyo
University of Pennsylvania
Known for Negishi coupling
Spouse(s) Suzuki Sumire
Children 2
Awards Sir Edward Frankland Prize Lectureship (2000)
Nobel Prize in Chemistry (2010)
Person of Cultural Merit (2010)
Order of Culture (2010)
Scientific career
Fields Chemistry
Institutions Teijin
Purdue University
Syracuse University
Hokkaido University
Doctoral advisor Allan R. Day
Influences Herbert Charles Brown

Ei-ichi Negishi (根岸 英一, Negishi Eiichi, born July 14, 1935[2]) is a Manchurian-born American chemist of Japanese origin who has spent most of his career at Purdue University in the United States. He is best known for his discovery of the Negishi coupling.[3] He was awarded the 2010 Nobel Prize in Chemistry "for palladium catalyzed cross couplings in organic synthesis" jointly with Richard F. Heck and Akira Suzuki.[4]

Early life and education[edit]

Negishi was born in Hsinking, the capital of Manchukuo (now Changchun, China) 1935,[5] following the transfer of his father who worked at the South Manchuria Railway in 1936, he moved to Harbin and spent his boyhood.[6] From 1943 to 1945, Negishi family moved to Incheon and Kyongsong Prefecture (now Seoul), both in Korea under Japanese rule. After World War II ended, they moved back to Japan in November 1945. Negishi graduated from the University of Tokyo in 1958[clarification needed] and did his internship at Teijin. He went on to study in the United States and obtained his PhD from the University of Pennsylvania in 1963 under the supervision of professor Allan R. Day.

Career[edit]

After obtaining PhD, Negishi decided to become an academic researcher.[7] Although he was hoping to work at a Japanese university, but he could not find any workplace.[8] In 1966 he handed off resignation of Teijin and he became a postdoctoral fellow at Purdue University. His advisor is Nobel laureate Herbert C. Brown.

In 1968, he became assistant professor. In 1972, he went on to become associate professor at Syracuse University where (formerly retired from Teijin), in 1979, he was promoted to professor, also he went back to Purdue University.

He discovered Negishi coupling which condenses organic zinc compound and organic halide under palladium or nickel catalyst to obtain C-C bonded product. With this achievement, he was awarded the Nobel Prize in Chemistry in 2010.[9] He commented that "I keep thinking for 50 years, dreaming has come true," and "that young Japanese people should also come overseas." Negishi have also reported that organoaluminum compounds and organic zirconium compounds can be used for cross-coupling. He has not obtained a patent for this coupling technology, his reason is as follows: "If we do not obtain a patent, we thought that everyone could use our results easily, and made it half conscious".[10]

In addition, Zr(C5H5)2 obtained by reducing zirconocene dichloride is also called Negishi reagent and is used for the synthesis of polysubstituted benzene.

Recognition[edit]

From left: Suzuki, Negishi, and Heck (2010)

In 2011, he was awarded the honorary doctor of science degree from the University of Pennsylvania.[11]

Awards[edit]

  • 1996 – A. R. Day Award (ACS Philadelphia Section award)
  • 1997 – Chemical Society of Japan Award
  • 1998 – Herbert N. McCoy Award
  • 1998 – American Chemical Society Award for Organometallic Chemistry
  • 1998-2000 – Alexander von Humboldt Senior Researcher Award
  • 2003 – Sigma Xi Award, Purdue University
  • 2007 – Yamada-Koga Prize
  • 2007 – Gold Medal of Charles University, Prague, Czech Republic
  • 2010 – Nobel Prize in Chemistry
  • 2010 – ACS Award for Creative Work in Synthetic Organic Chemistry

Honors[edit]

See also[edit]

References[edit]

  1. ^ https://www.nobelprize.org/nobel_prizes/chemistry/laureates/2010/press.html
  2. ^ Negishi's CV Archived 2010-10-24 at the Wayback Machine. on its lab's website
  3. ^ Anthony O. King, Nobuhisa Okukado and Ei-ichi Negishi (1977). "Highly general stereo-, regio-, and chemo-selective synthesis of terminal and internal conjugated enynes by the Pd-catalysed reaction of alkynylzinc reagents with alkenyl halides". Journal of the Chemical Society, Chemical Communications (19): 683. doi:10.1039/C39770000683. 
  4. ^ "Press release 6 October 2010". Royal Swedish Academy of Sciences. Retrieved 6 October 2010 .
  5. ^ "ノーベル化学賞に鈴木、根岸氏". 琉球新報. 2010-10-06. Archived from the original on 2010-11-30. Retrieved 2010-10-06. 
  6. ^ "(私の履歴書)根岸英一(2) 1年早く就学 8歳まで満州で生活 遊びに熱中、冬はスケート". 日本経済新聞. 日本経済新聞社. 2012-10-02. Retrieved 2015-08-30. 
  7. ^ (私の履歴書)根岸英一(10) 帝人に復帰 大学で「優」連発、自信に 新製品阻まれ学会へ転進、日本経済新聞、2012年10月10日
  8. ^ ノーベル化学賞:根岸さんうっすら涙「来るものが来た」、毎日新聞(電子版)、2010年10月7日
  9. ^ "ノーベル化学賞に鈴木名誉教授と根岸氏". 産経新聞. 2010-10-06. Archived from the original on 2010-10-06. Retrieved 2010-10-06. 
  10. ^ "根岸・鈴木氏、特許取得せず…栄誉の道開く一因". 読売新聞. 2010年10月7日12時46分. Archived from the original on 2010-10-09. Retrieved 2010年10月8日.  Check date values in: |access-date=, |date= (help)
  11. ^ Penn's 2011 Honorary Degree Recipients
  12. ^ "Professor Ei-ichi Negishi". J. Chem. Soc., Perkin Trans. 1. Royal Society of Chemistry (9): 9–xii. 2001. doi:10.1039/b009326m. 
  13. ^ Japanese Nobel Prize Chemists Honored By Royal Society Of Chemistry | Asian Scientist Magazine | Science, Technology and Medicine News Updates From Asia

External links[edit]