Gardini is a popular TV presenter, stage and screen actress. Her best-known television appearances have included Unomattina (1985–1986), Europa, Europa (1988–1990), and the leading role of Laura Andrei in Una donna per amico (1998–2000). Gardini was once close to the Christian Democracy and, after that party was dissolved into the Italian People's Party, she was an unsuccessful candidate for Segni Pact in the 1994 general election.
In 2004 she was appointed spokesperson of Forza Italia, with which she was elected to the Regional Council of Veneto in 2005 and to the Chamber of Deputies in 2006. In 2008 Gardini entered the European Parliament, replacing Renato Brunetta, and after the 2009 election she was returned for a full five-year term with The People of Freedom. She was once again re-elected in the 2014 election and was subsequently appointed leader of the new Forza Italia in the EP.
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