Hubley's hand-drawn films explore personal memory and the turbulence of emotional life. Among her shorts are Octave, Pigeon Within, Her Grandmother's Gift (in collaboration with her mother Faith), The Tower (in collaboration with her sister Georgia), and Delivery Man. In 2010, she completed a series of animated pieces for Motherhood: Out Loud, a new play presented at Hartford Stage between February and March 2010. Other animated sequences were provided by Hubley and Jeremiah Dickey to the documentary Everything’s Cool by Judith Helfand and Dan Gold, and The Boy in the Bubble by Barak Goodman and John Maggio. Other projects have included work for Disturbing the Universe: Radical Lawyer William Kunstler, directed by Emily and Sarah Kunstler, and What's On Your Plate?, directed by Catherine Gund. Her company, Hubbub Inc, also created short form series for the cable networks Nickelodeon and Lifetime.