Prager starred in The Edge of Night on television in the 1960s, and was a contributing editor of The National Lampoon, a performer on The National Lampoon Radio Hour and worked and appeared in The High School yearbook Parody. Her also work appeared in Titters, A Book of Humor by Women. She was a writer for, and briefly a cast member of Saturday Night Live. Although she did not appear in the single episode for which she was credited as a featured player, she had appeared uncredited in five previous episodes.
She was a writer-performer in the cult film, Mr. Mike's Mondo Video, and Robert Longo's Arena Brains. Her works include a compendium of her humor writing, In the Missionary Position, the acclaimed short story collection A Visit From the Footbinder and Other Stories, and the novels Eve's Tattoo, Clea and Zeus Divorce, and Roger Fishbite, and a memoirWuhu Diary. She has been a columnist for the Village Voice, the New York Times, the Daily Telegraph, Penthouse, and The Guardian. She is a Literary Lion of the New York Public Library and in the year 2000, she received the first online journalism award for commentary given by Columbia University Graduate School of Journalism. She taught at the Shanghai American School (Pudong Campus) in Shanghai, China. Dana Elcar was her stepfather. She has one adopted daughter, Lulu Prager. She is currently teaching in Islamabad, Pakistan.