End-diastolic volume

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In cardiovascular physiology, end-diastolic volume (EDV) is the volume of blood in the right and/or left ventricle at end load or filling in (diastole) or the amount of blood in the ventricles just before systole. Because greater EDVs cause greater distention of the ventricle, EDV is often used synonymously with preload, which refers to the length of the sarcomeres in cardiac muscle prior to contraction (systole). An increase in EDV increases the preload on the heart and, through the Frank-Starling mechanism of the heart, increases the amount of blood ejected from the ventricle during systole (stroke volume).

Parameters affecting EDV[edit]

Because nearly two-thirds of the blood in the systemic circulation is stored in the venous system, end-diastolic volume is closely related to venous compliance.

  • Increasing venous compliance elevates the capacitance of the veins, reducing venous return and therefore end-diastolic volume.
  • Decreasing venous compliance has the opposite effect. For example, activation of the baroreceptor reflex (occurring, for instance, in acute hemorrhage) causes vasoconstriction, which decreases venous compliance, improves venous return, and therefore increases end-diastolic volume.

Sample values[edit]

The values below are for the left ventricle:

Ventricular volumes
Measure Right ventricle Left ventricle
End-diastolic volume 144 mL(± 23mL)[1] 142 mL (± 21 mL)[2]
End-diastolic volume / body surface area (mL/m2) 78 mL (± 11 mL)[1] 78 mL (± 8.8 mL)[2]
End-systolic volume 50 mL (± 14 mL)[1] 47 mL (± 10 mL)[2]
End-systolic volume / body surface area (mL/m2) 27 mL (± 7 mL)[1] 26 mL (± 5.1 mL)[2]
Stroke volume 94 mL (± 15 mL)[1] 95 mL (± 14 mL)[2]
Stroke volume / body surface area (mL/m2) 51 mL (± 7 mL)[1] 52 mL (± 6.2 mL)[2]
Ejection fraction 66% (± 6%)[1] 67% (± 4.6%)[2]
Heart rate 60–100 bpm[3] 60–100 bpm[4]
Cardiac output 4.0–8.0 L/minute[5] 4.0–8.0 L/minute[5]

The right ventricular end-diastolic volume (RVEDV) ranges between 100 and 160 mL.[5] The right ventricular end-diastolic volume index (RVEDVI) is calculated by RVEDV/BSA and ranges between 60 and 100 mL/m2.[5]

See also[edit]

References[edit]

  1. ^ a b c d e f g Maceira, Alicia (2006). "Reference right ventricular systolic and diastolic function normalized to age, gender and body surface area from steady-state free precession cardiovascular magnetic resonance" (PDF). European Heart Journal. 27: 2879–2888. doi:10.1093/eurheartj/ehl336. Retrieved 6 November 2015. 
  2. ^ a b c d e f g Maceira, Alicia (2006). "Normalized Left Ventricular Systolic and Diastolic Function by Steady State Free Precession Cardiovascular Magnetic Resonance". Journal of Cardiovascular Magnetic Resonance. 8: 417–426. doi:10.1080/10976640600572889. Retrieved 6 November 2015. 
  3. ^ Normal ranges for heart rate are among the narrowest limits between bradycardia and tachycardia. See the Bradycardia and Tachycardia articles for more detailed limits.
  4. ^ Normal ranges for heart rate are among the narrowest limits between bradycardia and tachycardia. See the Bradycardia and Tachycardia articles for more detailed limits.
  5. ^ a b c d Edwards Lifesciences LLC > Normal Hemodynamic Parameters – Adult 2009