Endolymph is the fluid contained in the membranous labyrinth of the inner ear. The major cation in endolymph is potassium, with the values of sodium and potassium concentration in the endolymph being 0.91 mM and 154 mM, respectively. It is also called Scarpa's fluid, after Antonio Scarpa.
The inner ear has two parts: the bony labyrinth and the membranous labyrinth. The membranous labyrinth is contained within the bony labyrinth, and within the membranous labyrinth is a fluid called endolymph. Between the outer wall of the membranous labyrinth and the wall of the bony labyrinth is the location of perilymph.
Perilymph and endolymph have unique ionic compositions suited to their functions in regulating electrochemical impulses of hair cells. The electric potential of endolymph is ~80-90 mV more positive than perilymph due to a higher concentration of K compared to Na.
The main component of this unique extracellular fluid is potassium, which is secreted from the stria vascularis. The high potassium content of the endolymph means that potassium, not sodium, is carried as the de-polarizing electric current in the hair cells. This is known as the mechano-electric transduction (MET) current.
Endolymph has a high positive potential (80–120 mV in the cochlea), relative to other nearby fluids such as perilymph, due to its high concentration of positively charged ions. It is mainly this electrical potential difference that allows potassium ions to flow into the hair cells during mechanical stimulation of the hair bundle. Because the hair cells are at a negative potential of about -50 mV, the potential difference from endolymph to hair cell is on the order of 150 mV, which is the largest electrical potential difference found in the body.
Fluid waves occur in the endolymph in the various parts of the membranous labyrinth in response to fluid waves in the perilymph.
- Hearing: Cochlear duct: fluid waves in the endolymph of the cochlear duct stimulate the receptor cells, which in turn translate their movement into nerve impulses that the brain perceives as sound.
- Balance: Semicircular canals: angular acceleration of the endolymph in the semicircular canals stimulate the vestibular receptors of the endolymph. The semicircular canals of both inner ears act in concert to coordinate balance.
Disruption of the endolymph due to jerky movements (like spinning around or driving over bumps while riding in a car) can cause motion sickness. A condition where the volume of the endolymph is greatly enlarged is called endolymphatic hydrops and has been linked to Ménière's disease.
- Bosher SK, Warren RL (1968-11-05). "Observations on the electrochemistry of the cochlear endolymph of the rat: a quantitative study of its electrical potential and ionic composition as determined by means of flame spectrophotometry". Proceedings of the Royal Society B. 171 (1023): 227–247. doi:10.1098/rspb.1968.0066. PMID 4386844.
- synd/2926 at Who Named It?
- Konishi T, Hamrick PE, Walsh PJ (1978). "Ion transport in guinea pig cochlea. I. Potassium and sodium transport". Acta Otolaryngol. 86 (1–2): 22–34. doi:10.3109/00016487809124717. PMID 696294.
- What makes people dizzy when they spin?
- Ménière's Disease Information Center - Cause of Ménière's Disease
- https://web.archive.org/web/20051030092447/http://oto.wustl.edu/cochlea/res1.htmLongitudinal Flow of Endolymph at wustl.edu