Classification and external resources
Endometrioid tumors are a class of tumor characterized by a resemblance to endometrium/ endometrial carcinoma, and over a third of cases have focal squamous differentiation. [1 ]
Ovarian cancers in women aged 20+, with area representing relative incidence and color representing
5-year relative survival rate
[2 ] Endometrioid tumor
is labeled at bottom left.
They are part of the
surface epithelial tumor group of ovarian neoplasms (10–20% of which are the endometrioid type). Benign and borderline variants are rare, as the majority are malignant. There is an association with endometriosis and concurrent primary endometrial carcinoma ( endometrial cancer).
pathological examination, the tumor is cystic and may be solid and some arise in cystic endometriosis. In 40% of cases, endometrioid tumors are found bilaterally. [3 ]
Endometrium [ edit ]
Endometrioid carcinoma can also arise in the endometrium.
[4 ] [5 ]
Grades 1 and 2 are considered "type 1"
endometrial cancer, while grade 3 is considered "type 2". [6 ]
Molecular biology [ edit ]
CTNNB1 and PTEN mutations [ edit ]
Ovarian and endometrial endometrioid carcinomas have distinct
CTNNB1 and PTEN gene mutation profiles. PTEN mutations are more frequent in low-grade endometrial endometrioid carcinomas (67%) compared with low-grade ovarian endometrioid carcinomas (17%). By contrast, CTNNB1 mutations are significantly different in low-grade ovarian endometrioid carcinomas (53%) compared with low-grade endometrial endometrioid carcinomas (28%). This difference in CTNNB1 mutation frequency may be reflective of the distinct tumoral microenvironments; the epithelial cells lining an endometriotic cyst within the ovary are exposed to a highly oxidative environment that promotes tumorigenesis. [7 ]
References [ edit ]
^ "Dorlands Medical Dictionary:endometrioid tumor".
^ Kosary, Carol L. (2007). "Chapter 16: Cancers of the Ovary" (PDF). In Baguio, RNL; Young, JL; Keel, GE; Eisner, MP; Lin, YD; Horner, M-J. . SEER Program. NIH Pub. No. 07-6215. Bethesda, MD: National Cancer Institute. pp. 133–144. SEER Survival Monograph: Cancer Survival Among Adults: US SEER Program, 1988-2001, Patient and Tumor Characteristics
^ Robbins; Cotran, eds. (2005). Pathologic Basis of Disease (7th ed.). Philadelphia: Saunders. ISBN 0-7216-0187-1.
^ Mulvany NJ, Allen DG (January 2008). "Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium". Int. J. Gynecol. Pathol. 27 (1): 49–57. doi: 10.1097/pgp.0b013e31806219c5. PMID 18156975.
^ Carcinoma, Endometrioid at the US National Library of Medicine Medical Subject Headings (MeSH)
^ "ACS :: What Is Endometrial Cancer?" . Retrieved . 2010-03-24
^ McConechy, M. K.; Ding, J; Senz, J; Yang, W; Melnyk, N; Tone, A. A.; Prentice, L. M.; Wiegand, K. C.; McAlpine, J. N.; Shah, S. P.; Lee, C. H.; Goodfellow, P. J.; Gilks, C. B.; Huntsman, D. G. (2014). "Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles". Modern Pathology 27 (1): 128–34. doi: 10.1038/modpathol.2013.107. PMC 3915240. PMID 23765252.