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Endomorphin 1.svg
IUPAC name
3D model (JSmol)
Molar mass 610.703 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Endomorphin-1 (EM-1) (amino acid sequence Tyr-Pro-Trp-Phe-NH2) is an endogenous opioid peptide and one of the two endomorphins.[1] It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-2 (EM-2), has been proposed to be the actual endogenous ligand of the μ-receptor.[1][2][3][4] EM-1 produces analgesia in animals and is equipotent with morphine in this regard.[3] The gene encoding for EM-1 has not yet been identified.[4]

See also[edit]


  1. ^ a b Richard J. Bodnar; Kathryn Grace Commons; Donald W. Pfaff (3 April 2002). Central Neural States Relating Sex and Pain. JHU Press. pp. 67–. ISBN 978-0-8018-6827-6. 
  2. ^ H.-J. Krammer; M.V. Singer (31 May 2000). Neurogastroenterology - From the Basics to the Clinics. Springer Science & Business Media. pp. 76–. ISBN 978-0-7923-8757-2. 
  3. ^ a b Susan Brain; P.K. Moore (1999). Pain and Neurogenic Inflammation. Springer Science & Business Media. pp. 28–. ISBN 978-3-7643-5875-4. 
  4. ^ a b Stefan Offermanns; Walter Rosenthal (14 August 2008). Encyclopedia of Molecular Pharmacology. Springer Science & Business Media. pp. 904–. ISBN 978-3-540-38916-3.