Endonuclease/Exonuclease/phosphatase family

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Endonuclease/Exonuclease/phosphatase family
PDB 1ako EBI.jpg
Structure of the multifunctional DNA-repair enzyme exonuclease III.[1]
Identifiers
Symbol Exo_endo_phos
Pfam PF03372
InterPro IPR005135
PROSITE PDOC00598
SCOP 1ako
SUPERFAMILY 1ako
OPM superfamily 148
OPM protein 1zwx
CDD cd08372

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling.[2]

Examples[edit]

Subfamilies[edit]

Human proteins containing this domain[edit]

2'-PDE; 2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6; CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D; INPP5E; INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3; SYNJ1; SYNJ2; TTRAP;

Notes[edit]

  1. ^ Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA (March 1995). "Structure and function of the multifunctional DNA-repair enzyme exonuclease III". Nature. 374 (6520): 381–6. doi:10.1038/374381a0. PMID 7885481. 
  2. ^ Dlaki M (2000). "Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases". Trends Biochem. Sci. 25 (6): 272–273. doi:10.1016/S0968-0004(00)01582-6. PMID 10838565. 

References[edit]