Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCRgene. PROCR has also recently been designated CD201 (cluster of differentiation 201).
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C.
^Fukudome K, Esmon CT (Nov 1994). "Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor". J Biol Chem269 (42): 26486–91. PMID7929370.
^Rothbarth K, Dabaghian AR, Stammer H, Werner D (Oct 1999). "One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR)". FEBS Lett458 (1): 77–80. doi:10.1016/S0014-5793(99)01074-1. PMID10518938.
^Turner L, Lavstsen T, Berger SS, Wang CW, Petersen JE, Avril M, Brazier AJ, Freeth J, Jespersen JS, Nielsen MA, Magistrado P, Lusingu J, Smith JD, Higgins MK, Theander TG (2013). "Severe malaria is associated with parasite binding to endothelial protein C receptor". Nature. doi:10.1038/nature12216.
Laszik Z, Mitro A, Taylor FB; et al. (1998). "Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway.". Circulation96 (10): 3633–40. doi:10.1161/01.cir.96.10.3633. PMID9396465.
Ye X, Fukudome K, Tsuneyoshi N; et al. (1999). "The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries.". Biochem. Biophys. Res. Commun.259 (3): 671–7. doi:10.1006/bbrc.1999.0846. PMID10364477.
Simmonds RE, Lane DA (1999). "Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains.". Blood94 (2): 632–41. PMID10397730.
Liaw PC, Neuenschwander PF, Smirnov MD, Esmon CT (2000). "Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function.". J. Biol. Chem.275 (8): 5447–52. doi:10.1074/jbc.275.8.5447. PMID10681521.
Liaw PC, Mather T, Oganesyan N; et al. (2001). "Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor.". J. Biol. Chem.276 (11): 8364–70. doi:10.1074/jbc.M010572200. PMID11099506.
Biguzzi E, Merati G, Liaw PC; et al. (2002). "A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function.". Thromb. Haemost.86 (4): 945–8. PMID11686350.
von Depka M, Czwalinna A, Eisert R; et al. (2002). "Prevalence of a 23bp insertion in exon 3 of the endothelial cell protein C receptor gene in venous thrombophilia.". Thromb. Haemost.86 (6): 1360–2. PMID11776299.
Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature414 (6866): 865–71. doi:10.1038/414865a. PMID11780052.
Oganesyan V, Oganesyan N, Terzyan S; et al. (2002). "The crystal structure of the endothelial protein C receptor and a bound phospholipid.". J. Biol. Chem.277 (28): 24851–4. doi:10.1074/jbc.C200163200. PMID12034704.
Riewald M, Petrovan RJ, Donner A; et al. (2002). "Activation of endothelial cell protease activated receptor 1 by the protein C pathway.". Science296 (5574): 1880–2. doi:10.1126/science.1071699. PMID12052963.