Endothelin converting enzyme 1

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ECE1
3dwb.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ECE1, ECE, endothelin converting enzyme 1
External IDs MGI: 1101357 HomoloGene: 1068 GeneCards: ECE1
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ECE1
Genomic location for ECE1
Band 1p36.12 Start 21,217,247 bp[1]
End 21,345,504 bp[1]
RNA expression pattern
PBB GE ECE1 201749 at fs.png

PBB GE ECE1 201750 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001113347
NM_001113348
NM_001113349
NM_001397

NM_199307

RefSeq (protein)

NP_001106818
NP_001106819
NP_001106820
NP_001388
NP_001106820.1

NP_955011

Location (UCSC) Chr 1: 21.22 – 21.35 Mb Chr 1: 137.86 – 137.97 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene.[5][6][7]

Function[edit]

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117298 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057530 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: ECE1 endothelin converting enzyme 1". 
  6. ^ Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H (December 1994). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Lett. 356 (2–3): 238–43. PMID 7805846. doi:10.1016/0014-5793(94)01277-6. 
  7. ^ Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K (February 1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochem. Biophys. Res. Commun. 207 (2): 807–12. PMID 7864876. doi:10.1006/bbrc.1995.1258. 

Further reading[edit]