Endothelin converting enzyme 1

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ECE1
3dwb.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ECE1, ECE, endothelin converting enzyme 1
External IDs MGI: 1101357 HomoloGene: 1068 GeneCards: ECE1
Genetically Related Diseases
obesity[1]
RNA expression pattern
PBB GE ECE1 201749 at fs.png

PBB GE ECE1 201750 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001113347
NM_001113348
NM_001113349
NM_001397

NM_199307

RefSeq (protein)

NP_001106818
NP_001106819
NP_001106820
NP_001388
NP_001106820.1

NP_955011.1
NP_955011

Location (UCSC) Chr 1: 21.22 – 21.35 Mb Chr 4: 137.86 – 137.97 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene.[4][5][6]

Function[edit]

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.[4]

References[edit]

  1. ^ "Diseases that are genetically associated with ECE1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b "Entrez Gene: ECE1 endothelin converting enzyme 1". 
  5. ^ Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H (December 1994). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Lett. 356 (2–3): 238–43. doi:10.1016/0014-5793(94)01277-6. PMID 7805846. 
  6. ^ Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K (February 1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochem. Biophys. Res. Commun. 207 (2): 807–12. doi:10.1006/bbrc.1995.1258. PMID 7864876. 

Further reading[edit]