|Preferred IUPAC name
3D model (JSmol)
|Molar mass||297.18 g·mol−1|
|Appearance||Slightly yellow to brown solidified oil|
|Melting point||50 °C (122 °F; 323 K)|
|Boiling point||347 °C (657 °F; 620 K)|
|1400 mg/L (20 °C)|
|Flash point||181 °C (358 °F; 454 K)|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|227 mg/kg (oral rat)|
4200 mg/kg (dermal, rabbit)
16 mg/l/4 h (inhalation, rat)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|‹See TfM› (what is ‹See TfM› ?)|
In 1983, enilconazole was first introduced by Janssen Pharmaceutica and it has since consistently been registered as an antifungal postharvest agent. Shortly after its introduction, enilconazole was used for seed treatment in 1984 and later used in chicken hatcheries in 1990. Like any fungicide, it was used to protect crops from becoming diseased and unable to yield a profitable harvest. Today, it continues to be utilized as an agricultural aid for its contribution to maintaining crop integrity and production output.
Use on crops
Enilconazole is found on a wide variety of fruits and vegetables, but it is primarily used on tubers for storage. Common fungi that are attracted to tubers are Fusarium spp, Phoma spp, and Helminthosporum solani which depreciate the crop quality. In 1984, when enilconazole was initially used for seed treatment, barley was a main target to mitigate crop loss due to disease.
In addition, the antifungal agent is commonly used on citrus fruits.
The examples and perspective in this section deal primarily with the United States and do not represent a worldwide view of the subject. (August 2018) (Learn how and when to remove this template message)
In 1999, based on studies in rodents, enilconazole was identified as "likely to be carcinogenic in humans" under The Environmental Protection Agency's Draft Guidelines for Carcinogenic Assessment. However, because pesticide residues are well below the concentrations associated with risk, the lifetime cancer risk estimate associated with citrus fruit contamination was valued as insignificant.
The EPA has established an equivalent toxicity level for human exposure at 6.1 x 10−2 mg/kg/day. This level placed it in Category I, II, and IV for oral, dermal, and inhalation toxicity. Category I is classified as highly irritating to the eyes, but not to the skin. As for oral toxicity, when the fungicide is transferred via food into the body, it must be metabolized before it can do any damage.
The EPA determined there is no substantial risk to toxic levels when considering food and water exposure. Enilconazole has a very minute degree of mobility, so its level of drinking water contamination is quite low. The estimated environmental concentration (EEC) found the levels to be 0.072 ppb for surface water, which is much less than the 500 ppb comparison level for drinking water. These values are quite negligible, which is why the Agency does not see them as a concern.
- "Pesticide Information Profile: Imazalil". Extension Toxicology Network.
- Record in the GESTIS Substance Database of the Institute for Occupational Safety and Health
- Kaplan, H. J.; Dave, B. A. (1979). "The current status of Imazalil: a post harvest fungicide for citrus". Proceedings of the Florida State Horticultural Society. 92: 37–43.
- EMA Committee for Veterinary Products: Enilconazole
- "R.E.D. Facts: Imazalil" (PDF). Environmental Protection Agency. February 2005.
- "Imazalil". Certis Europe.
- Proposition 65, Office of Environmental Health Hazard Assessment