Enoyl-acyl carrier protein reductase

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Enoyl-acyl carrier protein reductase
5cp8.jpg
Enoyl-[acyl-carrier-protein] reductase [NADH] tetramer, Mycobacterium tuberculosis
Identifiers
EC number 1.3.1.9
CAS number 37251-08-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

Enoyl-acyl carrier protein reductase (or ENR) (EC 1.3.1.9), is a key enzyme of the type II fatty acid synthesis (FAS) system.[1] ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes.[2]

FattyAcid-MB-Reduction2.png

At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR. Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria Streptococcus pneumoniae.[3]

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References[edit]

  1. ^ Kapoor M, Gopalakrishnapai J, Surolia N, Surolia A (August 2004). "Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum". The Biochemical Journal. 381 (Pt 3): 735–41. doi:10.1042/BJ20040302. PMC 1133883Freely accessible. PMID 15139852. 
  2. ^ Ling LL, Xian J, Ali S, Geng B, Fan J, Mills DM, Arvanites AC, Orgueira H, Ashwell MA, Carmel G, Xiang Y, Moir DT (May 2004). "Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase". Antimicrobial Agents and Chemotherapy. 48 (5): 1541–7. PMC 400533Freely accessible. PMID 15105103. 
  3. ^ Zheng CJ, Sohn MJ, Kim WG (December 2006). "Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae". The Journal of Antibiotics. 59 (12): 808–12. doi:10.1038/ja.2006.108. PMID 17323650. 

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