Initially he was taught by his father Leander, later on, between 1806 and 1810, he studied both at the University of Bologna and at the Academy of Fine Arts of Bologna. In 1822 he was commissioned by general Ludwik Michał Pac to complete his palace in Dowspuda (then in Congress Poland, now in north-eastern Poland). He settled in Warsaw, where from 1827 he worked for the Council of State and where he became professor (1851-1858) at the Academy of Fine Arts.
Enrico Marconi married a daughter of general Pac's gardener, Małgorzata (English: Margaret) Heiton, who came from a Scottish family settled in Poland. One of their sons, Leandro, also became an architect.
- Hotel Europejski in Warsaw
- Mausoleum of Stanisław Kostka Potocki in Wilanów
- The Pumping Room Building at Wilanów Palace
- Rail stations in Warsaw, Granica and Sosnowiec on the Warsaw-Vienna Railway
- Water tower in Saxon Garden, Warsaw
- Great Synagogue, Łomża
- All Saints Church, Warsaw
- The English Landscape Park at the Wilanów Palace Museum