Enrique (or Henrique) Flórez de Setién y Huidobro (July 21, 1702 – August 20, 1773) was a Spanish historian.
Flórez was born in Villadiego. At 15 years old, he entered the order of St Augustine. He subsequently became professor of theology at the University of Alcala, where he published a Cursus theologiae in five volumes (1732–1738). He then devoted himself to historical studies. Of these the first-fruit was his Clavis Historiae, a work of the same class as the French Art de verifier les dates, and preceding it by several years. It appeared in 1743, and passed through many editions.
In 1747 was published the first volume of España Sagrada, teatro geografico-historico de La Iglesia de España, a vast compilation of Spanish ecclesiastical history which obtained a European reputation, and of which twenty-nine volumes appeared in the author's lifetime. It was continued after his death by Manuel Risco and others, and further additions have been made at the expense of the Spanish government. The whole work in fifty-one volumes was published at Madrid (1747–1886). Its value is considerably increased by the insertion of ancient chronicles and documents not easily accessible elsewhere.
Flórez was a good numismatist, and published Medallas de Las Colonias in 2 vols. (1757–1758), of which a third volume appeared in 1773. His last work was the Memorias de las reynas Catolicas, 2 vols. (1770). Flórez led a retired, studious and unambitious life, and died at Madrid.