Enterobacteria greA leader

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Enterobacteria greA leader
Enterobacteria greA leader.png
Conserved secondary structure of greA leader, colours represent the fraction of canonical base pairs
Identifiers
Symbol greA_leader
Rfam RF01769
Other data
RNA type Cis-reg; leader
Domain(s) Enterobacteriales
SO {{{SO}}}

The Enterobacteria greA leader is a putative attenuator element identified by bioinformatics within bacteria of the γ-proteobacterial Enterobacteriales order.[1] It is located upstream of the rnk gene, encoding a transcription elongation factor, and presents a Rho-independent terminator at the 3' end. This RNA is presumed to operate as a non-coding leader, which regulatory mechanism remains to be elucidated.[1] The short abortive form of the greA transcript may also play a role as an independent sRNA: Potrykus et al. have shown that its overexpression leads to the repression of several genes.[2] The motif might be related to other rnk leaders such as the Pseudomonas rnk leader and the Enterobacteria rnk leader.[1]

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References[edit]

  1. ^ a b c Naville, M; Gautheret, D (2010). "Premature terminator analysis sheds light on a hidden world of bacterial transcriptional attenuation.". Genome Biology. 11 (9): R97. PMC 2965389Freely accessible. PMID 20920266. doi:10.1186/gb-2010-11-9-r97. 
  2. ^ Potrykus, K; Murphy, H; Chen, X; Epstein, JA; Cashel, M (Mar 2010). "Imprecise transcription termination within Escherichia coli greA leader gives rise to an array of short transcripts, GraL.". Nucleic Acids Research. 38 (5): 1636–51. PMC 2836576Freely accessible. PMID 20008510. doi:10.1093/nar/gkp1150. 

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