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This article is about the organism. For the infection, see Enterobiasis.
This article is about the nematode of the family Enterobius, known as pinworm in the US. For the different nematode known as pinworm in the rest of the world, see Strongyloides stercoralis.

ICD-9 127.4, ICD-10 B80

Evermicularis SC posterior.jpg
Pinworms(U.S.)/Threadworms(U.K.) (Enterobius vermicularis).
Scientific classification
Kingdom: Animalia
Phylum: Nematoda
Class: Secernentea
Subclass: Spiruria
Order: Oxyurida
Family: Oxyuridae
Genus: Enterobius
  • Enterobius vermicularis (Linnaeus, 1758)[1]
  • Enterobius anthropopitheci (Gedoelst, 1916)[1]
  • Enterobius gregorii (Hugot, 1983) (disputed)[2][3][4]

The pinworm (species Enterobius vermicularis), also known as threadworm (in the United Kingdom and Australasia) or seatworm, is a parasitic worm. It is a nematode (roundworm) and a common intestinal parasite or helminth, especially in humans.[5] The medical condition associated with pinworm infestation is known as enterobiasis[6] (a type of helminthiasis) or less precisely as oxyuriasis in reference to the family Oxyuridae.[7]

Throughout this article, the word "pinworm" refers to Enterobius. In British usage, however, pinworm refers to Strongyloides, while Enterobius is called threadworm.[8]


The pinworm (genus Enterobius) is a type of roundworm (nematode), and three species of pinworm have been identified with certainty.[9] Humans are hosts only to Enterobius vermicularis (formerly Oxyurias vermicularis).[10] Chimpanzees are host to Enterobius anthropopitheci, which is morphologically distinguishable from the human pinworm.[3] Hugot (1983) claims another species affects humans, Enterobius gregorii, which is supposedly a sister species of E. vermicularis, and has a slightly smaller spicule (i.e., sexual organ).[11] Its existence is controversial, however; Totkova et al. (2003) consider the evidence to be insufficient,[4] and Hasegawa et al. (2006) contend that E. gregorii is a younger stage of E. vermicularis.[2][3] Regardless of its status as a distinct species, E. gregorii is considered clinically identical to E. vermicularis.[10]


Two female pinworms next to a ruler: The markings are 1 mm apart.

The adult female has a sharply pointed posterior end, is 8 to 13 mm long, and 0.5 mm thick.[12] The adult male is considerably smaller, measuring 2 to 5 mm long and 0.2 mm thick, and has a curved posterior end.[12] The eggs are translucent[12] and have a surface that adheres to objects.[13] The eggs measure 50 to 60 μm by 20 to 30 μm, and have a thick shell flattened on one side.[12] The small size and colourlessness of the eggs make them invisible to the naked eye, except in barely visible clumps of thousands of eggs. Eggs may contain a developing embryo or a fully developed pinworm larva.[12] The larvae grow to 140–150 μm in length.[13]


The pinworm has a worldwide distribution,[14] and is the most common helminth (i.e., parasitic worm) infection in the United States, western Europe, and Oceania.[15][16] In the United States, a study by the Center of Disease Control reported an overall incidence rate of 11.4% among children.[16] Pinworms are particularly common in children, with prevalence rates in this age group having been reported as high as 61% in India, 50% in England, 39% in Thailand, 37% in Sweden, and 29% in Denmark.[16] Finger sucking has been shown to increase both incidence and relapse rates,[16] and nail biting has been similarly associated.[17] Because it spreads from host to host through contamination, pinworms are common among people living in close contact, and tends to occur in all people within a household.[14] The prevalence of pinworms is not associated with gender,[14] nor with any particular social class, race, or culture.[16] Pinworms are an exception to the tenet that intestinal parasites are uncommon in affluent communities.[16]
A fossilized nematode egg was detected in 240 million-year-old fossil dung,[18] showing that parasitic pinworms already infested pre-mammalian cynodonts. The earliest known instance of the pinworms associated with humans is evidenced by pinworm eggs found in human coprolites carbon dated to 7837 BC found in western Utah.[13]


Lifecycle of E. vermicularis showing the stages inside and outside of the human body

The entire lifecycle, from egg to adult, takes place in the human gastrointestinal tract of a single host,[12][13] from about 2–4 weeks[19] or about 4–8 weeks.[16]

The lifecycle begins with eggs being ingested.[13] The eggs hatch in the duodenum (i.e., first part of the small intestine).[20] The emerging pinworm larvae grow rapidly to a size of 140 to 150 μm,[19] and migrate through the small intestine towards the colon.[13] During this migration, they moult twice and become adults.[13][16] Females survive for 5 to 13 weeks, and males about 7 weeks.[13] The male and female pinworms mate in the ileum (i.e., last part of the small intestine),[13] whereafter the male pinworms usually die,[20] and are passed out with stool.[21] The gravid female pinworms settle in the ileum, caecum (i.e., beginning of the large intestine), appendix and ascending colon,[13] where they attach themselves to the mucosa[16] and ingest colonic contents.[14]

Almost the entire body of a gravid female becomes filled with eggs.[20] The estimations of the number of eggs in a gravid female pinworm range from about 11,000[13] to 16,000.[16] The egg-laying process begins about five weeks after initial ingestion of pinworm eggs by the human host.[13] The gravid female pinworms migrate through the colon towards the rectum at a rate of 12 to 14 cm per hour.[13] They emerge from the anus, and while moving on the skin near the anus, the female pinworms deposit eggs either through (1) contracting and expelling the eggs, (2) dying and then disintegrating, or (3) bodily rupture due to the host scratching the worm.[20] After depositing the eggs, the female becomes opaque and dies.[21] The reason the female emerges from the anus is to obtain the oxygen necessary for the maturation of the eggs.[21]


Main article: Enterobiasis

E. vermicularis causes the medical condition enterobiasis, whose primary symptom is itching in the anal area.[22]


Albendazole or mebendazole is the first-line treatment of pinworm infection. Pyrantel pamoate is an alternative. Among naturopathic cures, garlic, wormwood, black walnut and papaya seeds have been used historically. People of the Middle East have used Za'atar since ancient times to reduce and eliminate internal parasites.[23] Za'atar uses large quantities of Thyme (Thymus serpyllum) which contains phenolic, antimicrobial and antiseptic compounds including the essential oil and anthelmintic thymol. Thymol has also been used in alcohol solutions and in dusting powders for the treatment of tinea or ringworm infections, and was used in the United States to treat hookworm infections.[24]


Pinworms spread through human-to-human transmission, by ingesting (i.e., swallowing) infectious pinworm eggs and/or by anal insertion.[16][20] The eggs are hardy and can remain viable (i.e., infectious) in a moist environment up to three weeks.[16][21] They do not tolerate heat well, but can survive in low temperatures: two-thirds of the eggs are still viable after 18 hours at −8 °C (18 °F).[21]

After the eggs have been initially deposited near the anus, they are readily transmitted to other surfaces through contamination.[20] The surface of the eggs is sticky when laid,[13][21] and the eggs are readily transmitted from their initial deposit near the anus to fingernails, hands, night-clothing and bed linen.[19] From here, eggs are further transmitted to food, water, furniture, toys, bathroom fixtures and other objects.[13][16][20] Household pets often carry the eggs in their fur, while not actually being infected.[25] Dust containing eggs can become airborne and widely dispersed when dislodged from surfaces, for instance when shaking out bed clothes and linen.[16][21][25] Consequently, the eggs can enter the mouth and nose through inhalation, and be swallowed later.[16][19][20][21] Although pinworms do not strictly multiply inside the body of their human host,[19] some of the pinworm larvae may hatch on the anal mucosa, and migrate up the bowel and back into the gastrointestinal tract of the original host[16][19] in a process called retroinfection.[16][21] When this retroinfection occurs, it can lead to a heavy parasitic load and ensures the pinworm infestation continues[16] or can be not clinically significant.[21] Despite the limited, 13-week lifespan of individual pinworms,[13] autoinfection (i.e., infection from the original host to itself), either through the anus-to-mouth route or through retroinfection, usually necessitates repeated treatment, at 2-week intervals, in order to remove the infection completely.[26]


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