Medial surface. (Entorhinal cortex approximately maps to areas 28 and 34, at lower left.)
Medial surface of right hemisphere. Entorhinal cortex visible at near bottom.
|Part of||Temporal lobe|
|NeuroLex ID||Entorhinal Cortex|
|Anatomical terms of neuroanatomy|
The entorhinal cortex (EC) (ento = interior, rhino = nose, entorhinal = interior to the rhinal sulcus) is an area of the brain located in the medial temporal lobe and functioning as a hub in a widespread network for memory and navigation. The EC is the main interface between the hippocampus and neocortex. The EC-hippocampus system plays an important role in declarative (autobiographical/episodic/semantic) memories and in particular spatial memories including memory formation, memory consolidation, and memory optimization in sleep. The EC is also responsible for the pre-processing (familiarity) of the input signals in the reflex nictitating membrane response of classical trace conditioning, the association of impulses from the eye and the ear occurs in the entorhinal cortex.
In rodents, the EC is located at the caudal end of the temporal lobe. In primates it is located at the rostral end of the temporal lobe and stretches dorsolaterally. It is usually divided into medial and lateral regions with three bands with distinct properties and connectivity running perpendicular across the whole area. A distinguishing characteristic of the EC is the lack of cell bodies where layer IV should be; this layer is called the lamina dissecans.
Inputs and outputs
The superficial layers - layers II and III - of EC project to the dentate gyrus and hippocampus: Layer II projects primarily to dentate gyrus and hippocampal region CA3; layer III projects primarily to hippocampal region CA1 and the subiculum. These layers receive input from other cortical areas, especially associational, perirhinal, and parahippocampal cortices, as well as prefrontal cortex. EC as a whole, therefore, receives highly processed input from every sensory modality, as well as input relating to ongoing cognitive processes, though it should be stressed that, within EC, this information remains at least partially segregated.
The deep layers, especially layer V, receive one of the three main outputs of the hippocampus and, in turn, reciprocate connections from other cortical areas that project to superficial EC.
The rodent entorhinal cortex shows a modular organization, with different properties and connections in different areas.
Neuron information processing
In 2005, it was discovered that entorhinal cortex contains a neural map of the spatial environment in rats. In 2014, John O'Keefe, May-Britt Moser and Edvard Moser received the Nobel Prize for Physiology or Medicine, partly because of this discovery.
Neurons in the lateral entorhinal cortex exhibit little spatial selectivity, whereas neurons of the medial entorhinal cortex (MEA), exhibit multiple "place fields" that are arranged in an hexagonal pattern, and are, therefore, called "grid cells". These fields and spacing between fields increase from the dorso-lateral MEA to the ventro-medial MEA.
The same group of researchers have found speed cells in the medial entorhinal cortex of rats. The speed of movement is translated from proprioceptive information and is represented as firing rates in these cells. The cells are known to fire in correlation to future speed of the rodent. 
Single-unit recording of neurons in humans playing video games find path cells in the EC, the activity of which indicates whether a person is taking a clockwise or counterclockwise path. Such EC "direction" path cells show this directional activity irrespective of the location of where a person experiences themselves, which contrasts them to place cells in the hippocampus, which are activated by specific locations.
EC neurons process general information such as directional activity in the environment, which contrasts to that of the hippocampal neurons, which usually encode information about specific places. This suggests that EC encodes general properties about current contexts that are then used by hippocampus to create unique representations from combinations of these properties.
The entorhinal cortex is the first area of the brain to be affected in Alzheimer's disease; a recent functional magnetic resonance imaging study has localised the area to the lateral entorhinal cortex. Lopez et al.  have showed, in a multimodal study, that there are differences in the volume of the LEFT entorhinal cortex between progressing (to Alzheimer's disease) and stable mild cognitive impairment patients. These authors also found that the volume of the left entorhinal cortex inversely correlates with the level of alpha band phase synchronization between the right anterior cingulate and temporo-occipital regions.
In 2012, neuroscientists at UCLA conducted an experiment using a virtual taxi video game connected to seven epilepsy patients with electrodes already implanted in their brains, allowing the researchers to monitor neuronal activity whenever memories were being formed. As the researchers stimulated the nerve fibers of each of the patients' entorhinal cortex as they were learning, they were then able to better navigate themselves through various routes and recognize landmarks more quickly. This signified an improvement in the patients' spatial memory.
- Brodmann area 28 is known as the "area entorhinalis"
- Brodmann area 34 is known as the "area entorhinalis dorsalis"
- Hafting T, Fyhn M, Molden S, Moser M, Moser E (2005). "Microstructure of a spatial map in the entorhinal cortex". Nature 436 (7052): 801–6. Bibcode:2005Natur.436..801H. doi:10.1038/nature03721. PMID 15965463.
- "Overview of Nobel Prize laureates in Physiology or Medicine".
- Hargreaves E, Rao G, Lee I, Knierim J (2005). "Major dissociation between medial and lateral entorhinal input to dorsal hippocampus". Science 308 (5729): 1792–4. Bibcode:2005Sci...308.1792H. doi:10.1126/science.1110449. PMID 15961670.
- Fyhn M, Molden S, Witter M, Moser E, Moser M (2004). "Spatial representation in the entorhinal cortex". Science 305 (5688): 1258–64. Bibcode:2004Sci...305.1258F. doi:10.1126/science.1099901. PMID 15333832.
- Kropff Em, Carmichael J E, Moser M-B, Moser E-I (2015). "Speed cells in the medial entorhinal cortex". Nature 523: 419–424. Bibcode:2015Natur.523..419K. doi:10.1038/nature14622.
- Jacobs J, Kahana MJ, Ekstrom AD, Mollison MV, Fried I (2010). "A sense of direction in human entorhinal cortex". Proc Natl Acad Sci U S A 107 (14): 6487–6492. Bibcode:2010PNAS..107.6487J. doi:10.1073/pnas.0911213107. PMC 2851993. PMID 20308554.
- Khan UA, Liu L, Provenzano FA, Berman DE, Profaci CP, Sloan R, Mayeux R, Duff KE, Small SA. (2013). "Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer’s disease". Nature Neuroscience. doi:10.1038/nn.3606.
- Lopez, M. E.; Bruna, R.; Aurtenetxe, S.; Pineda-Pardo, J. A.; Marcos, A.; Arrazola, J.; Reinoso, A. I.; Montejo, P.; Bajo, R.; Maestu, F. (2014). "Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study". Journal of Neuroscience 34 (44): 14551–14559. doi:10.1523/JNEUROSCI.0964-14.2014.
- Suthana, N.; Haneef, Z.; Stern, J.; Mukamel, R.; Behnke, E.; Knowlton, B.; Fried, I. (2012). "Memory Enhancement and Deep-Brain Stimulation of the Entorhinal Area". New England Journal of Medicine. doi:10.1056/NEJMoa1107212.
- Stained brain slice images which include the "Entorhinal cortex" at the BrainMaps project
- NIF Search - Entorhinal Cortex via the Neuroscience Information Framework
For delineating the Entorhinal cortex, see Desikan RS, Ségonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT, Albert MS, Killiany RJ. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage. 2006 Jul 1;31(3):968-80.