Eosinophil-derived neurotoxin

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Protein RNASE2 PDB 1gqv.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesRNASE2, EDN, RAF3, RNS2, ribonuclease A family member 2
External IDsOMIM: 131410 MGI: 1858598 HomoloGene: 121614 GeneCards: RNASE2
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for RNASE2
Genomic location for RNASE2
Band14q11.2Start20,955,487 bp[1]
End20,956,436 bp[1]
RNA expression pattern
PBB GE RNASE2 206111 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 14: 20.96 – 20.96 MbChr 14: 51.16 – 51.16 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Eosinophil-derived neurotoxin is an enzyme that in humans is encoded by the RNASE2 gene.[5][6][7]

The protein encoded by this gene is found in eosinophil granulocytes. It is closely related to the eosinophil cationic protein (RNASE3) from which it diverged ~50 million years ago after the split between the old world and the new world monkeys.[8] It is relatively neutral and has cytotoxic properties. It is capable of reducing the activity of single strand RNA viruses in culture through its enzymatic activity. It also serves as an attractant to immune cells.

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169385 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059606 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.
  6. ^ Rosenberg HF, Tenen DG, Ackerman SJ (Jul 1989). "Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family". Proc Natl Acad Sci U S A. 86 (12): 4460–4. doi:10.1073/pnas.86.12.4460. PMC 287289. PMID 2734298.
  7. ^ "Entrez Gene: RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)".
  8. ^ Rosenberg, Helene F. (2008-05-01). "RNase A ribonucleases and host defense: an evolving story". Journal of Leukocyte Biology. 83 (5): 1079–1087. doi:10.1189/jlb.1107725. ISSN 1938-3673. PMC 2692241. PMID 18211964.

Further reading[edit]

External links[edit]