Eosinophilic ulcer of the oral mucosa

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Eosinophilic ulcer of the oral mucosa. H&E stain.

Eosinophilic ulcer of the oral mucosa (also known as eosinophilic ulcer of the tongue,[1] Riga–Fede disease,[1] and traumatic eosinophilic granuloma[1]) is a condition characterized by an ulcer with an indurated and elevated border.[2]:803 The lesion might be tender, fast-growing and the patient often not be aware of any trauma in the area.


It is often associated with trauma. However, other causes are suspected, such as drugs, inherent predisposition, immune reaction, or lymphoproliferative disorder.


Differential Diagnosis[edit]

Squamous Cell Carcinoma, Pyogenic granulomas, Lesions of a chronic granulomatous disease and Mesenchymal tumors


Traumatic eosinophilic granuloma of the tongue (TEGT) is a reactive condition that commonly occurs on the ventral tongue.


When the lesion is excised, recurrence often occurs. Palliative care with nonsteroidal anti-inflammatory drugs (NSAIDs) may be used, and topical steroids can be curative. If the lesion does not respond to treatment, biopsy is required.

See also[edit]


  1. ^ a b c Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  2. ^ James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 

3. Ficarra G, Prignano F, Romagnoli P. Traumatic eosinophilic granuloma of the oral mucosa: A lymphoproliferative disorder? Oral Oncol.1997;33(5):375-379.