Ephrin A2

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EFNA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEFNA2, ELF-1, EPLG6, HEK7-L, LERK-6, LERK6, ephrin A2
External IDsOMIM: 602756 MGI: 102707 HomoloGene: 1075 GeneCards: EFNA2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for EFNA2
Genomic location for EFNA2
Band19p13.3Start1,285,873 bp[1]
End1,301,431 bp[1]
RNA expression pattern
PBB GE EFNA2 208256 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001405

NM_007909

RefSeq (protein)

NP_001396

NP_031935

Location (UCSC)Chr 19: 1.29 – 1.3 MbChr 10: 80.18 – 80.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene.[5]

This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099617 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003070 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: EFNA2 ephrin-A2".

Further reading[edit]