Epigen

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EPGN
Identifiers
AliasesEPGN, ALGV3072, EPG, PRO9904, epithelial mitogen
External IDsMGI: 1919170 HomoloGene: 19527 GeneCards: EPGN
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for EPGN
Genomic location for EPGN
Band4q13.3Start74,308,470 bp[1]
End74,316,789 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_053087

RefSeq (protein)

NP_001257918
NP_001257919
NP_001257920
NP_001257921
NP_001257922

NP_444317

Location (UCSC)Chr 4: 74.31 – 74.32 MbChr 5: 91.03 – 91.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene.[5][6]

Function[edit]

The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182585 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035020 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Epithelial mitogen".
  6. ^ Schneider MR, Yarden Y (2014). "Structure and function of epigen, the last EGFR ligand". Semin. Cell Dev. Biol. 28: 57–61. doi:10.1016/j.semcdb.2013.12.011. PMC 4037347. PMID 24374012.

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.