Transverse section of human tibial nerve. (Epineurium labeled at upper right.)
The epineurium is the outermost layer of dense irregular connective tissue surrounding a peripheral nerve. It usually surrounds multiple nerve fascicles as well as blood vessels which supply the nerve. Smaller branches of these blood vessels penetrate into the perineurium. In addition to blood vessels which supply the nerve, lymphocytes and fibroblasts are also present and contribute to the production of collagen fibers that form the backbone of the epineurium. In addition to providing structural support, lymphocytes and fibroblasts also play a vital role in maintenance and repair of the surrounding tissues.
When the spinal nerve leaves the vertebral canal via an intervertebral foramen, two layers of the spinal meninges, the arachnoid and the dura invaginate the nerve to form a dural sleeve of connective tissue, which is the epineurium. The outer portion of this sleeve comprises the external epineurium which permits longitudinal nerve excursion and absorption of longitudinal stress. The layer of the epineurium that extends within the nerve to define the fascicles is termed the internal epineurium. Together, these two layers form the epineurium, which varies in thickness along the course of a nerve.  The epineurium is usually most abundant around joints, as its function is to protect the nerves from stretching and subsequent injury. A common surgical procedure to repair a torn nerve via the epineurium is termed an epineurial repair. 
- McCracken, Thomas (1999). New Atlas of Human Anatomy. China: Metro Books. pp. 96–97. ISBN 1-5866-3097-0.
- Kulkarni, GS (2009). Textbook of Orthopaedics and Trauma. India: Jaypee Brothers Medical Publication. pp. 895–898. ISBN 9350908522.
- Payne, Samuel H. (2001). "Nerve Repair and Grafting in the Upper Extremity". Journal of the Southern Orthopaedic Association (Medscape) 10 (2): 1–7. Retrieved 22 March 2015.
- Saladin, Kenneth (2014). Anatomy & Physiology: The Unity of Form and Function. USA: McGraw-Hill Science. pp. 484–485. ISBN 0073403717.
- Anatomy photo: nervous/pns/nerve1/nerve1 - Comparative Organology at University of California, Davis - "PNS, nerve (LM, Low)"
- Anatomy photo: nervous/pns/nerve2/nerve1 - Comparative Organology at University of California, Davis - "PNS, nerve (LM, Medium)"
- Diagram at Howard