The album opening track, "Tallahassee Love" featuring J Lyriq, contains a slightly sample of 2Pac's hit song "California Love". The album's fifth track "I Got It", following by the album's sixth track "Suicide", it deals with the subject of HIV/AIDS and it seems to be interconnected.
The album's second single, titled "Bartender", was released on June 5, 2007. The song features a guest appearances from Akon, and the production was handled by T-Pain himself, who also produced the song "Buy U a Drank (Shawty Snappin')" latter released as the lead single. The song has since peaked at number 5 on the US Billboard Hot 100.
Epiphany received generally mixed reviews from music critics, who drew comparisons to fellow R&B singer R. Kelly. Gentry Boeckel of PopMatters credited T-Pain on his production and his use of various characters on the songs he wrote. He also said that his career will last more than other past R&B artists like Case, Joe and Tyrese concluding with, "T-Pain does seem posed for more success than those other guys. He may even be worth the verbiage, too." John Hanson of Sputnikmusic also praised the album for its production complimenting the songs (specifically the singles) saying, "T-Pain is starting to establish himself as a lasting source of entertainment in the vein of R. Kelly." Meka Udoh of HipHopDX credited songs like "Time Machine" and "Suicide" for bringing out a semi-serious T-Pain but was put off by his use of multiple characters throughout the album saying, "While Epiphany has its moments, it is also its schizophrenic nature that bogs the album down." David Jeffries of AllMusic questioned the album being 'mature', finding that side not mixing together with the party side of T-Pain's music. Norman Mayers of Prefix criticized the album for bringing out "the worst stereotypes of black music and culture" in the R&B genre saying, "Epiphany is a profound statement on the poor quality and embarrassing content found in mainstream urban music."