Epithelial-myoepithelial carcinoma

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Epithelial-myoepithelial carcinoma
Epithelial-myoepithelial carcinoma - very high mag.jpg
Micrograph of an epithelial-myoepithelial carcinoma (right of image). The epithelial component has a tubular morphology and is evident only focally (upper left of image). Benign serous glands (parotid salivary gland) are also seen (left of image). H&E stain.
Classification and external resources

Epithelial-myoepithelial carcinoma, abbreviated EMCa, is a rare malignant tumour that typically arises in a salivary gland and consists of both an epithelial and myoepithelial component. They are predominantly found in the parotid gland[1] and represent approximately 1% of salivary gland tumours.[2]



EMCas are diagnosed by examination of tissue, e.g. a biopsy.

Its appearance is very similar to adenomyoepithelioma of the breast, which may be the same tumour at a different anatomical site.[3]

The histologic differential diagnosis includes adenoid cystic carcinoma and pleomorphic adenoma.


They generally have a good prognosis.[1] In one larger study, the 5-year and 10-year survival were over 90% and 80% respectively.[4]

See also[edit]

Additional images[edit]


  1. ^ a b Kasper, HU.; Mellin, W.; Kriegsmann, J.; Cheremet, E.; Lippert, H.; Roessner, A. (1999). "Epithelial-myoepithelial carcinoma of the salivary gland--a low grade malignant neoplasm? Report of two cases and review of the literature". Pathol Res Pract. 195 (3): 189–92. doi:10.1016/S0344-0338(99)80033-8. PMID 10220800.
  2. ^ Tralongo, V.; Daniele, E. (1998). "Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature". Anticancer Res. 18 (1B): 603–8. PMID 9568184.
  3. ^ Seifert, G. (Sep 1998). "Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?". Virchows Arch. 433 (3): 285–8. PMID 9769134.
  4. ^ Seethala, RR.; Barnes, EL.; Hunt, JL. (Jan 2007). "Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract". Am J Surg Pathol. 31 (1): 44–57. doi:10.1097/01.pas.0000213314.74423.d8. PMID 17197918.