Epsilon cell

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Epsilon cell
Location Islets of Langerhans
Function Ghrelin production
TH H3.
Anatomical terms of microanatomy

Epsilon cells (ε-cells) are endocrine cells found in the Islets of Langerhans and produce the hormone ghrelin. They were discovered in mice.

Epsilon Cells During Development[edit]

In human fetal pancreases, single epsilon cells scattered in primitive exocrine tissue were observed to start aggregating into clusters after gestational week 13. From gestational week 21, epsilon cells were observed around developing islets, forming an almost continuous layer at the rim of the islets. In adult pancreas samples, they remained localized on the mantle of the islets in different amounts. Production of ghrelin with insulin, glucagon, or somatostatin was not detected during development. Co-production with pancreatic polypeptide was evident sporadically.[1]

See also[edit]


  1. ^ Andralojc, K. M; Mercalli, A; Nowak, K. W; Albarello, L; Calcagno, R; Luzi, L; Bonifacio, E; Doglioni, C; Piemonti, L (2008). "Ghrelin-producing epsilon cells in the developing and adult human pancreas". Diabetologia. 52 (3): 486–93. doi:10.1007/s00125-008-1238-y. PMID 19096824.

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