Epstein–Barr virus viral-capsid antigen

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The Epstein–Barr virus viral-capsid antigen (EBV-VCA) is the viral protein that forms the viral capsid of the Epstein–Barr virus. It is the antigen targeted by anti-VCA antibodies.[clarification needed] Such antibodies can be used in serology to diagnose infectious mononucleosis. In cases with primary infection, the sensitivity of IgG (immunoglobulin) [clarification needed] and IgM[clarification needed] anti-VCA testing has been estimated to be 100% reliable.[1]

Elevated Anti-VCA IgM indicates acute infection.

Elevated Anti-VCA IgG indicates prior infection.


  1. ^ Robertson, P.; Beynon, S.; Whybin, R.; Brennan, C.; Vollmer-Conna, U.; Hickie, I.; Lloyd, A. (2003). "Measurement of EBV-IgG anti-VCA avidity aids the early and reliable diagnosis of primary EBV infection". Journal of Medical Virology. 70 (4): 617–623. doi:10.1002/jmv.10439. PMID 12794726.