Epstein–Barr virus vaccine
Epstein–Barr virus vaccine is a term for a vaccine against the Epstein–Barr virus. The virus establishes persistent/latent infection and causes infectious mononucleosis. Vaccines are not yet available, but it is in clinical trials. The viral protein Gp350/220 is the primary target and MVA-EL[further explanation needed] has been also proposed as a target.
One challenge is that the Epstein–Barr virus expresses very different proteins during its lytic and its latent phases. To address this, vaccine candidates have been designed to include proteins from both phases.
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- "WHO | Viral Cancers". Retrieved 2009-01-15.
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- Lockey, T.D.; Zhan, X.; Surman, S.; Sample, C.E.; Hurwitz, J.L. (2008). "Epstein-Barr virus vaccine development: a lytic and latent protein cocktail". Front. Biosci. 13 (13): 5916–27. doi:10.2741/3126. PMID 18508632.
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