Eptazocine

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Eptazocine
Eptazocine.svg
Systematic (IUPAC) name
(1S,6S)-1,4-dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonin-10-ol
Clinical data
Legal status
  • (Prescription only)
Routes of
administration
Oral
Identifiers
CAS Registry Number 72522-13-5
72150-17-5 (bromide)
ATC code None
PubChem CID: 3042090
ChemSpider 2305268
UNII 2208ZLI77S
Chemical data
Formula C15H21NO
Molecular mass 231.333 g/mol

Eptazocine (Sedapain) is an opioid analgesic which was introduced in Japan by Morishita in 1987.[1][2][3][4] It acts as a mixed κ-opioid receptor agonist and μ-opioid receptor antagonist.[4][5][6]

See also[edit]

References[edit]

  1. ^ Index nominum 2000: international drug directory. Taylor & Francis US. 2000. p. 396. ISBN 978-3-88763-075-1. Retrieved 29 November 2011. 
  2. ^ American Chemical Society. Division of Medicinal Chemistry (1990). Annual Reports in Medicinal Chemistry. Academic Press. p. 381. ISBN 978-0-12-040525-1. Retrieved 29 November 2011. 
  3. ^ Nabeshima T, Matsuno K, Kamei H, Kameyama T (May 1985). "The interaction of eptazocine, a novel analgesic, with opioid receptors". Research Communications in Chemical Pathology and Pharmacology 48 (2): 173–81. PMID 2992058. 
  4. ^ a b Hiroshi Nagase; Silvia N. Calderon (21 January 2011). Chemistry of Opioids. Springer. p. 280. ISBN 978-3-642-18106-1. Retrieved 29 November 2011. 
  5. ^ Tamura T, Ogawa J, Taniguchi T, Waki I (January 1990). "[Preferential action of eptazocine, a novel analgesic, with opioid receptors in isolated guinea pig ileum and mouse vas deferens preparations]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese) 95 (1): 41–6. doi:10.1254/fpj.95.1_41. PMID 2154395. 
  6. ^ Dr. Ian Morton; Ian K. M. Morton; Judith M. Hall; Dr. Judith Hall (1999). Concise dictionary of pharmacological agents: properties and synonyms. Springer. p. 113. ISBN 978-0-7514-0499-9. Retrieved 29 November 2011.