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|Chemical and physical data|
|Molar mass||547.05 g/mol g·mol−1|
|3D model (JSmol)|
Erastin is a small molecule capable of initiating ferroptotic cell death. Erastin binds and inhibits VDAC2 and VDAC3 and functionally inhibits the cystine-glutamate antiporter System Xc-. Cells treated with erastin are deprived of cysteine and are unable to synthesize the antioxidant glutathione. Depletion of glutathione eventually leads to excessive lipid peroxidation and cell death.
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- Yagoda, N; von Rechenberg, M; Zaganjor, E; Bauer, AJ; Yang, WS; Fridman, DJ; Wolpaw, AJ; Smukste, I; Peltier, JM; Boniface, JJ; Smith, R; Lessnick, SL; Sahasrabudhe, S; Stockwell, BR (14 June 2007). "RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels". Nature. 447 (7146): 864–8. PMID 17568748.
- Dixon, SJ; Patel, DN; Welsch, M; Skouta, R; Lee, ED; Hayano, M; Thomas, AG; Gleason, CE; Tatonetti, NP; Slusher, BS; Stockwell, BR (20 May 2014). "Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis". eLife. 3: e02523. PMID 24844246.
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